Advancements in Spinal Cord Injury Repair: Insights from Dental-Derived Stem Cells

被引：6
作者：
Wen, Xueying [1 ]
Jiang, Wenkai [2 ]
Li, Xiaolin [1 ]
Liu, Qian [3 ]
Kang, Yuanyuan [1 ]
Song, Bing [3 ,4 ]
机构：
[1] China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China
[2] Fourth Mil Med Univ, Natl Clin Res Ctr Oral Dis, Sch Stomatol, Shaanxi Key Lab Stomatol,State Key Lab Oral & Maxi, Xian 710032, Peoples R China
[3] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
[4] Cardiff Univ, Sch Dent, Heath Pk, Cardiff CF14 4XY, Wales
来源：
BIOMEDICINES | 2024年 / 12卷 / 03期
基金：
中国国家自然科学基金;
关键词：
spinal cord injury; stem cell therapy; neural repair; dental-derived stem cells; dental pulp stem cells; stem cells from human exfoliated deciduous teeth; stem cells from the apical papilla; dental follicle stem cells; delivery system; tissue regeneration; DECIDUOUS TEETH; FOLLICLE CELLS; IN-VITRO; REGENERATION; CONTUSION; RECOVERY; THERAPY; TRANSPLANTATION; TRANSECTION; DISLOCATION;
D O I：
10.3390/biomedicines12030683
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Spinal cord injury (SCI), a prevalent and disabling neurological condition, prompts a growing interest in stem cell therapy as a promising avenue for treatment. Dental-derived stem cells, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from the apical papilla (SCAP), dental follicle stem cells (DFSCs), are of interest due to their accessibility, minimally invasive extraction, and robust differentiating capabilities. Research indicates their potential to differentiate into neural cells and promote SCI repair in animal models at both tissue and functional levels. This review explores the potential applications of dental-derived stem cells in SCI neural repair, covering stem cell transplantation, conditioned culture medium injection, bioengineered delivery systems, exosomes, extracellular vesicle treatments, and combined therapies. Assessing the clinical effectiveness of dental-derived stem cells in the treatment of SCI, further research is necessary. This includes investigating potential biological mechanisms and conducting Large-animal studies and clinical trials. It is also important to undertake more comprehensive comparisons, optimize the selection of dental-derived stem cell types, and implement a functionalized delivery system. These efforts will enhance the therapeutic potential of dental-derived stem cells for repairing SCI.
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页数：17
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