Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

被引：6

作者：

Mishra, Atreyee ^{[1
]}

Djoko, Karrera Y. ^{[2
]}

Lee, Yi-Hsuan ^{[3
]}

Lord, Rianne M. ^{[3
]}

Kaul, Grace ^{[4
,5
]}

Akhir, Abdul ^{[4
]}

Saxena, Deepanshi ^{[4
]}

Chopra, Sidharth ^{[4
,5
]}

Walton, James W. ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] Univ Durham, Dept Biosci, Durham DH1 3LE, England

[3] Univ East Anglia, Sch Chem, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England

[4] CSIR Cent Drug Res Inst, Div Mol Microbiol & Immunol, Sitapur Rd,Sect 10, Lucknow 226031, Uttar Pradesh, India

[5] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 12期

关键词：

ANTICANCER; AGENTS;

D O I：

10.1039/d2ob01224c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper Pyrithione, [Cu(PyS)(2)] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(ii) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)(2)], has particularly impressive anticancer activity, surpassing that of the parent complex.

引用

页码：2539 / 2544

页数：6

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