The Gut Microbiome and Metastatic Renal Cell Carcinoma

被引：10

作者：

Meza, Luis ^{[1
]}

Feng, Matthew ^{[1
]}

Lee, Kyle ^{[1
]}

Sperandio, Rubens ^{[2
]}

Pal, Sumanta Kumar ^{[1
]}

机构：

[1] City Hope Comprehens Canc Ctr, Dept Med Oncol & Expt Therapeut, Duarte, CA 91010 USA

[2] Hosp Israelita Albert Einstein, BR-05652900 Sao Paulo, Brazil

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 04期

关键词：

renal cell carcinoma; gut microbiome; translational research; TARGETED THERAPY; INTERFERON-ALPHA; DIETARY FIBER; CANCER; BACTERIA; IMMUNOTHERAPY; EFFICACY; IMPACT; DIFFERENTIATION; MODULATION;

D O I：

10.3390/jcm12041502

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The introduction of targeted therapy (TT) and immuno-oncology (IO) agents have revolutionized the treatment of metastatic renal cell carcinoma (mRCC). However, despite the significant improvements in survival and clinical response yielded by these agents, a significant percentage of patients still experience progressive disease. Evidence now suggests that microorganisms living in the gut (i.e., the gut microbiome) could be used as a biomarker for response and may also have utility in increasing response to these treatments. In this review, we present an overview of the role of the gut microbiome in cancer and its potential implications in the treatment of mRCC.

引用

页数：13

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