Myocardial work-A new tool for early detection of rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone chemotherapy induced-cardiotoxicity in hematological patients

被引:5
作者
Mihalcea, Diana [1 ,2 ,3 ]
Memis, Hayat [2 ,3 ]
Balinisteanu, Anca [2 ,3 ]
Vladareanu, Ana-Maria [1 ,2 ,3 ]
Mihaila, Sorina [1 ,2 ,3 ]
Vinereanu, Dragos [1 ,2 ,3 ]
机构
[1] Univ Med & Pharm Carol Davila, Fac Med, Bucharest, Romania
[2] Univ Bucharest, Cardiol Dept, Bucharest, Romania
[3] Emergency Hosp, Splaiul Independentei 169, Bucharest 050098, Romania
关键词
cardiotoxicity; echocardiography; lymphoma; myocardial work; SPECKLE TRACKING ECHOCARDIOGRAPHY; 3-DIMENSIONAL ECHOCARDIOGRAPHY; CONSENSUS DOCUMENT; DIASTOLIC FUNCTION; QUANTIFICATION; BIOMARKERS; AGREEMENT; SURVIVORS;
D O I
10.1002/jcu.23388
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Background Rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (RCHOP) chemotherapy in non-Hodgkin's lymphoma (NHL) has risk of cardiotoxicity. Purpose To determine the role of myocardial work and biomarkers in subclinical diagnosis and prediction of cardiotoxicity. Methods The 130 NHL patients (52 +/- 9 years, 62% men) scheduled for RCHOP, with LVEF>50%, were evaluated at baseline, after third cycle and chemotherapy completion for 3D LVEF, 2D myocardial deformation (longitudinal, radial, circumferential strain - LS, RS, CS) and myocardial work (global constructive work, waste work, work index and work efficiency - GCW, GWW, GWI, GWE). NT-pro-BNP and troponin I were determined. Results After chemotherapy ended, 37 patients (28%) (group I) developed asymptomatic cardiotoxicity (8 mild form, 25 moderate form, 4 severe form); 93 patients (group II) did not. After third cycle, all patients had decreased LS, CS, RS, GCW, GWI, GWE and increased GWW, persistent after chemotherapy completion, with significant changes in group I. After third cycle, GWE and GCW were the best independent predictors for LVEF reduction; GWE decrease with>5% after third cycle predicted cardiotoxicity after chemotherapy completed (91% sensitivity, 94% specificity). Conclusions In NHL, myocardial work can diagnose subclinical cardiotoxicity and predict LVEF decline. These parameters should be used for sensitive evaluation of myocardial function during chemotherapy.
引用
收藏
页码:377 / 384
页数:8
相关论文
共 29 条
  • [1] [Anonymous], 2021, CANC STAT FACTS
  • [2] Three-dimensional full automated software in the evaluation of the left ventricle function: from theory to clinical practice
    Barletta, Valentina
    Hinojar, Rocio
    Carbonell, Alejandra
    Gonzalez-Goemez, Ariana
    Fabiani, Iacopo
    Di Bello, Vitantonio
    Julio Jimenez-Nacher, Jose
    Zamorano, Jose
    Fernandez-Golfin, Covadonga
    [J]. INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2018, 34 (08) : 1205 - 1213
  • [3] STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
    BLAND, JM
    ALTMAN, DG
    [J]. LANCET, 1986, 1 (8476) : 307 - 310
  • [4] Two-dimensional speckle tracking echocardiography predicts early subclinical cardiotoxicity associated with anthracycline-trastuzumab chemotherapy in patients with breast cancer
    Calle, Maria C. Arciniegas
    Sandhu, Nicole P.
    Xia, Hongmei
    Cha, Stephen S.
    Pellikka, Patricia A.
    Ye, Zi
    Herrmann, Joerg
    Villarraga, Hector R.
    [J]. BMC CANCER, 2018, 18
  • [5] A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy
    Chan, Jonathan
    Edwards, Natalie F. A.
    Khandheria, Bijoy K.
    Shiino, Kenji
    Sabapathy, Surendran
    Anderson, Bonita
    Chamberlain, Robert
    Scalia, Gregory M.
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2019, 20 (01) : 31 - 39
  • [6] Global Myocardial Work Is Superior to Global Longitudinal Strain to Predict Significant Coronary Artery Disease in Patients With Normal Left Ventricular Function and Wall Motion
    Edwards, Natalie F. A.
    Scalia, Gregory M.
    Shiino, Kenji
    Sabapathy, Surendran
    Anderson, Bonita
    Chamberlain, Robert
    Khandheria, Bijoy K.
    Chan, Jonathan
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2019, 32 (08) : 947 - 957
  • [7] Global Left Ventricular Myocardial Work Efficiency in Healthy Individuals and Patients with Cardiovascular Disease
    El Mahdiui, Mohammed
    van der Bijl, Pieter
    Abou, Rachid
    Marsan, Nina Ajmone
    Delgado, Victoria
    Bax, Jeroen J.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2019, 32 (09) : 1120 - 1127
  • [8] Early Detection of Epirubicin-Induced Cardiotoxicity in Patients with Breast Cancer
    Florescu, Maria
    Magda, Lucia Stefania
    Enescu, Oana Aurelia
    Jinga, Dan
    Vinereanu, Dragos
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2014, 27 (01) : 83 - 92
  • [9] Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging
    Galderisi, Maurizio
    Cosyns, Bernard
    Edvardsen, Thor
    Cardim, Nuno
    Delgado, Victoria
    Di Salvo, Giovanni
    Donal, Erwan
    Sade, Leyla Elif
    Ernande, Laura
    Garbi, Madalina
    Grapsa, Julia
    Hagendorff, Andreas
    Kamp, Otto
    Magne, Julien
    Santoro, Ciro
    Stefanidis, Alexandros
    Lancellotti, Patrizio
    Popescu, Bogdan
    Habib, Gilbert
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2017, 18 (12) : 1301 - 1310
  • [10] Myocardial constructive work and cardiac mortality in resynchronization therapy candidates
    Galli, Elena
    Hubert, Arnaud
    Le Rolle, Virginie
    Hernandez, Alfredo
    Smiseth, Otto A.
    Mabo, Philippe
    Leclercq, Christophe
    Donal, Erwan
    [J]. AMERICAN HEART JOURNAL, 2019, 212 : 53 - 63