Advances in the Synthesis and Bio-Applications of Pyrazine Derivatives: A Review

被引：16

作者：

Choudhary, Dimple ^{[1
]}

Garg, Sonali ^{[1
]}

Kaur, Manvinder ^{[1
]}

Sohal, Harvinder Singh ^{[1
]}

Malhi, Dharambeer Singh ^{[1
]}

Kaur, Loveleen ^{[1
]}

Verma, Meenakshi ^{[1
]}

Sharma, Ajay ^{[1
]}

Mutreja, Vishal ^{[1
]}

机构：

[1] Chandigarh Univ, Dept Chem, Med & Nat Prod Lab, Gharuan 140413, Mohali, India

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 05期

关键词：

Pyrazine; heterocyclic compound; intermolecular cyclization; intramolecular cyclization; MOLTEN-SALT CATALYST; B METHYL-ESTER; HETEROCYCLIC-COMPOUNDS; EFFICIENT SYNTHESIS; ONE-POT; QUINOXALINE DERIVATIVES; BIOLOGICAL EVALUATION; ORGANIC FRAMEWORKS; NATURAL-PRODUCTS; DISCOVERY;

D O I：

10.1080/10406638.2022.2092873

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heterocycles are significant class of compound in organic chemistry, due to their substantial pharmacological application and development of new materials, as well as their prevalence in natural products. Pyrazine is one of the most essential types of N-heterocycles, which is a useful compound in organic chemistry and has a wide range of commercial applications. It has recently been the focus of a number of techniques, owing to its widespread use as a framework in the synthesis of bioactive components, catalysts, and reactions in various media. Pyrazine compounds comprise a variety of pharmacological action, including antipyretic, anti-inflammatory, analgesic, anticancer, antibacterial, and antioxidant activity. It can be used to carry out different types of coupling reaction i.e., Suzuki, Buchwald Hartwig, oxidative coupling reactions. This review aims to summarize the recent work done pyrazine synthesis and the latest report of the last six years going in the field of pyrazine synthesis.

引用

页码：4512 / 4578

页数：67

共 247 条

[91] The first stable examples of compounds containing both diazonium and acyl azide, and synthesis of a new pyrazino[2′,3′:3,4]pyrazolo[5,1-c] [1,2,4]triazin-4(6H)-one heterocyclic system [J].

Ivanov, Sergey M. ;

Mironovich, Lyudmila M. ;

Rodinovskaya, Lyudmila A. ;

Shestopalov, Anatoliy M. .

TETRAHEDRON LETTERS, 2017, 58 (19) :1851-1853

[92] New dimensions in triazolo[4,3-a]pyrazine derivatives: The land of opportunity in organic and medicinal chemistry [J].

Jethava, Divya J. ;

Borad, Mayuri A. ;

Bhoi, Manoj N. ;

Acharya, Prachi T. ;

Bhaysar, Zeel A. ;

Patel, Hitesh D. .

ARABIAN JOURNAL OF CHEMISTRY, 2020, 13 (12) :8532-8591

[93] Synthesis, properties and application of novel 5,6,5,6-tetracyclic pyrazine/pyrrole-fused unsymmetric bis(BF2) fluorescent dyes: BOPYPYs [J].

Jiang, Xindong ;

Yue, Shuai ;

Chen, Kepeng ;

Shao, Zhumei ;

Li, Chen ;

Su, Yajun ;

Zhao, Jianzhang .

CHINESE CHEMICAL LETTERS, 2019, 30 (12) :2271-2273

[94] Molecular Interactions of Pyrazine-Based Compounds to Proteins [J].

Juhas, Martin ;

Zitko, Jan .

JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (17) :8901-8916

[95]

Karci F, 2005, COLOR TECHNOL, V121, P275

[96] Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent [J].

Katoh, A ;

Yoshida, T ;

Ohkanda, J .

HETEROCYCLES, 2000, 52 (02) :911-920

[97] A Review on Synthesis, Reactions and Biological Properties of Seven Membered Heterocyclic Compounds: Azepine, Azepane, Azepinone [J].

Kaur, Manvinder ;

Garg, Sonali ;

Malhi, Dharambeer S. ;

Sohal, Harvinder S. .

CURRENT ORGANIC CHEMISTRY, 2021, 25 (04) :449-506

[98] Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry [J].

Keri, Rangappa S. ;

Hiremathad, Asha ;

Budagumpi, Srinivasa ;

Nagaraja, Bhari Mallanna .

CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 86 (01) :799-845

[99] A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications [J].

Kerru, Nagaraju ;

Gummidi, Lalitha ;

Maddila, Suresh ;

Gangu, Kranthi Kumar ;

Jonnalagadda, Sreekantha B. .

MOLECULES, 2020, 25 (08)

[100] Facile synthesis of hexahydropyrazino[2,3-e]pyrazines from 3-aminomethyl-1,2,4-triazoles [J].

Khomenko, Dmytro M. ;

Doroschuk, Roman O. ;

Trachevskii, Vladimir V. ;

Shova, Sergiu ;

Lampeka, Rostyslav D. .

TETRAHEDRON LETTERS, 2016, 57 (09) :990-992

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