The effects of metabolism on the immune microenvironment in colorectal cancer

被引：18

作者：

Chen, Xingzhao ^{[1
]}

Ma, Zhiyuan ^{[1
]}

Yi, Zhiqiang ^{[1
]}

Wu, Enqin ^{[1
]}

Shang, Zhengye ^{[1
]}

Tuo, Biguang ^{[1
]}

Li, Taolang ^{[2
]}

Liu, Xuemei ^{[1
]}

机构：

[1] Zunyi Med Univ, Digest Dis Hosp, Affiliated Hosp, Dept Gastroenterol, Zunyi, Guizhou, Peoples R China

[2] Zunyi Med Univ, Dept Gen Surg, Affiliated Hosp, Dalian Rd 149, Zunyi 563000, Peoples R China

来源：

CELL DEATH DISCOVERY | 2024年 / 10卷 / 01期

关键词：

COLON-CANCER; TUMOR-GROWTH; CELLS; RECEPTOR; AXIS; P53; POLARIZATION; METASTASIS; TRYPTOPHAN; EXPRESSION;

D O I：

10.1038/s41420-024-01865-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Colorectal cancer (CRC) is a malignancy that is widely prevalent worldwide. Due to its unsatisfactory treatment outcome and extremely poor prognosis, many studies on the molecular mechanisms and pathological mechanisms of CRC have been published in recent years. The tumor microenvironment (TME) is an extremely important feature of tumorigenesis and one of the hallmarks of tumor development. Metabolic reprogramming is currently a hot topic in tumor research, and studies on this topic have provided important insights into CRC development. In particular, metabolic reprogramming in cancer causes changes in the composition of energy and nutrients in the TME. Furthermore, it can alter the complex crosstalk between immune cells and associated immune factors, such as associated macrophages and T cells, which play important immune roles in the TME, in turn affecting the immune escape of tumors by altering immune surveillance. In this review, we summarize several metabolism-related processes affecting the immune microenvironment of CRC tumors. Our results showed that the immune microenvironment is regulated by metabolic reprogramming and influences the development of CRC.

引用

页数：11

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