A dual biofunctional hydrogel (HQCS-SP) wound dressing, offering antibacterial properties and a biological response, was innovatively designed and developed to repair full-layer skin defects. The HQCS-SP hydrogel creates an artificial matrix that facilitates cell recruitment, extracellular matrix deposition, exhibiting exceptional tissue affinity, robust self-healing, effective hemostatic capabilities and accelerates wound healing. It is synthesized by crosslinking modified chitosan (HQCS) with spirulina protein (SP) and Fe3+. The HQCS provides antibacterial, antioxidant, good tissue affinity and excellent hemostasis performance. The incorporation of SP not only reinforces the antioxidant, antibacterial, anti-inflammatory, and pro-angiogenesis effects but also participates in the regulation of signal pathways and promotes wound healing. Therefore, this study offers a new visual angle for the design of advanced functional trauma dressings with great application potential in the bio-medical field.
机构:
Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Movaffagh, Jebrail
Fazly-Bazzaz, Bibi-Seddigheh
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Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Fazly-Bazzaz, Bibi-Seddigheh
Yazdi, Abbas Tabatabaei
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Mashhad Univ Med Sci, Qaem Hosp, Dept Pathol, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Yazdi, Abbas Tabatabaei
Sajadi-Tabassi, Abolghasem
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Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Sajadi-Tabassi, Abolghasem
Azizzadeh, Mohammad
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Ferdowsi Univ Mashhad, Dept Clin Sci, Fac Vet Med, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Azizzadeh, Mohammad
Najafi, Esmaeel
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Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Najafi, Esmaeel
Amiri, Nafise
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Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Amiri, Nafise
Taghanaki, Hamidreza Bahrami
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Mashhad Univ Med Sci, Fac Persian & Complementary Med, Dept Chinese & Complementary Med, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Taghanaki, Hamidreza Bahrami
Ebrahimzadeh, Mbhammad Hossein
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Mashhad Univ Med Sci, Orthoped Res Ctr, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Ebrahimzadeh, Mbhammad Hossein
Moradi, Ali
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Mashhad Univ Med Sci, Orthoped Res Ctr, Mashhad, Razavi Khorasan, Iran
Mashhad Univ Med Sci, Qaem Hosp, Clin Res Unit, Fac Med, Mashhad, Razavi Khorasan, IranMashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran
Moradi, Ali
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE,
2019,
31
(09):
: 228
-
235
机构:
Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Liang, Yongping
Zhao, Xin
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Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Zhao, Xin
Hu, Tianli
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Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Hu, Tianli
Chen, Baojun
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Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Chen, Baojun
Yin, Zhanhai
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Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Yin, Zhanhai
Ma, Peter X.
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机构:
Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USAXi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Ma, Peter X.
Guo, Baolin
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Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710049, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
机构:
ICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Yuan Ze Univ, Grad Inst Med, Taoyuan 32003, TaiwanICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Sharun, Khan
Mamachan, S. Merlin
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ICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Mamachan, S. Merlin
Mamachan, Merlin
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ICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Mamachan, Merlin
Subash, Athira
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ICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Subash, Athira
Karikalan, Mathesh
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ICAR Indian Vet Res Inst, Ctr Wildlife Conservat Management & Dis Surveillan, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Karikalan, Mathesh
Kumar, Rohit
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ICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Kumar, Rohit
Vinodhkumar, Obli Rajendran
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ICAR Indian Vet Res Inst, Div Epidemiol, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Vinodhkumar, Obli Rajendran
Dhama, Kuldeep
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ICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India
Dhama, Kuldeep
Pawde, A. M.
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ICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, IndiaICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India