Compound Microalgae-Type Biofunctional Hydrogel for Wound Repair during Full-Thickness Skin Injuries

被引:1
|
作者
Mao, Yi [1 ]
Sun, Yajuan [1 ]
Yang, Cheng [1 ]
机构
[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Synthet & Biol Colloids, Minist Educ, Wuxi 214122, Peoples R China
基金
中国国家自然科学基金;
关键词
chitosan/spirulina hydrogel; antibacterial; antioxidant; hemostatic; anti-inflammatory; wound healing; ANTIBACTERIAL; SPIRULINA; PHYCOCYANIN; HEMOSTASIS; DELIVERY;
D O I
10.3390/polym16050692
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A dual biofunctional hydrogel (HQCS-SP) wound dressing, offering antibacterial properties and a biological response, was innovatively designed and developed to repair full-layer skin defects. The HQCS-SP hydrogel creates an artificial matrix that facilitates cell recruitment, extracellular matrix deposition, exhibiting exceptional tissue affinity, robust self-healing, effective hemostatic capabilities and accelerates wound healing. It is synthesized by crosslinking modified chitosan (HQCS) with spirulina protein (SP) and Fe3+. The HQCS provides antibacterial, antioxidant, good tissue affinity and excellent hemostasis performance. The incorporation of SP not only reinforces the antioxidant, antibacterial, anti-inflammatory, and pro-angiogenesis effects but also participates in the regulation of signal pathways and promotes wound healing. Therefore, this study offers a new visual angle for the design of advanced functional trauma dressings with great application potential in the bio-medical field.
引用
收藏
页数:18
相关论文
共 50 条
  • [11] Injectable Adhesive Self-Healing Multicross-Linked Double-Network Hydrogel Facilitates Full-Thickness Skin Wound Healing
    Yang, Bo
    Song, Jiliang
    Jiang, Yuhang
    Li, Ming
    Wei, Jingjing
    Qin, Jiajun
    Peng, Wanjia
    Lasaosa, Fernando Lopez
    He, Yiyan
    Mao, Hongli
    Yang, Jun
    Gu, Zhongwei
    ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (52) : 57782 - 57797
  • [12] Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing
    Magin, Chelsea M.
    Neale, Dylan B.
    Drinker, Michael C.
    Willenberg, Bradley J.
    Reddy, Shravanthi T.
    La Perle, Krista M. D.
    Schultz, Gregory S.
    Brennan, Anthony B.
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2016, 241 (09) : 986 - 995
  • [13] Conductive Adhesive and Antibacterial Zwitterionic Hydrogel Dressing for Therapy of Full-Thickness Skin Wounds
    Wang, Feng
    Wang, Shuguang
    Nan, Liping
    Lu, Jiawei
    Zhu, Ziqi
    Yang, Jintao
    Zhang, Dong
    Liu, Junjian
    Zhao, Xiao
    Wu, Desheng
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10
  • [14] Effect of Honey/PVA Hydrogel Loaded by Erythromycin on Full-Thickness Skin Wound Healing in Rats; Stereological Study
    Movassaghi, Shabnam
    Sharifi, Zahra Nadia
    Koosha, Mojtaba
    Abdollahifar, Mohammad Amin
    Fathollahipour, Shahrzad
    Tavakoli, Javad
    Abdi, Shabnam
    GALEN MEDICAL JOURNAL, 2019, 8
  • [15] Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing
    Zhang, Wenchang
    Qi, Xiaomin
    Zhao, Yan
    Liu, Yunen
    Xu, Lei
    Song, Xiaoqiang
    Xiao, Chenjuan
    Yuan, Xiaoxue
    Zhang, Jinsong
    Hou, Mingxiao
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 586
  • [16] Rapid creation of skin substitutes from human skin cells and biomimetic nanofibers for acute full-thickness wound repair
    Mahjour, Seyed Babak
    Fu, Xiaoling
    Yang, Xiaochuan
    Fong, Jason
    Sefat, Farshid
    Wang, Hongjun
    BURNS, 2015, 41 (08) : 1764 - 1774
  • [17] One-Step Synthesis of Multifunctional Chitosan Hydrogel for Full-Thickness Wound Closure and Healing
    Guo, Shen
    Yao, Minghao
    Zhang, Dan
    He, Yuanmeng
    Chang, Rong
    Ren, Yikun
    Guan, Fangxia
    ADVANCED HEALTHCARE MATERIALS, 2022, 11 (04)
  • [18] The Effects of Nitrofurazone on Wound Healing in Thoracoabdominal Full-thickness Skin Defects
    Karapolat, Sami
    Karapolat, Banu
    Buran, Alaaddin
    Okatan, Burcu Kemal
    Turkyilmaz, Atila
    Set, Turan
    Tekinbas, Celal
    WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, 2020, 32 (05): : 134 - 141
  • [19] An injectable sodium-mangiferin homopolymeric hydrogel accelerated skin full-thickness wound healing in guinea pig model
    Wang, Ning-Xiang
    Huang, Mei-Rong
    Huang, Min
    Lv, Jun-Mei
    Wei, Pei-Ning
    Li, Sun-Han
    Ding, Shilei
    Yang, Tao
    BIOMEDICAL MATERIALS, 2025, 20 (01)
  • [20] Evaluation of the Efficiency of Chitosan Hydrogel Containing Berberis integerrima Root Extract on a Full-Thickness Skin Wound in a Rat Model
    Maryam Hashemi
    Fatemeh Kalalinia
    Mobina Razi
    Fatemeh Moameri
    Bibi Sedigheh Fazly Bazzaz
    Mehrdad Iranshahi
    Jebrail Movaffagh
    Macromolecular Research, 2022, 30 : 527 - 535