miR-182 promotes cervical cancer progression via activating the Wnt/β-catenin axis

被引：0
作者：
Gao, Fei [1 ]
Yin, Jilai [1 ]
Wang, Yongcun [2 ]
Li, Hao [1 ]
Wang, Daping [1 ]
机构：
[1] Hainan Med Coll, Affiliated Hosp 1, Haikou, Hainan, Peoples R China
[2] Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2023年 / 13卷 / 08期
关键词：
Cervical cancer; miR-182; Wnt/beta-catenin axis; cancer progression; metastasis; ABERRANT ACTIVATION; BETA-CATENIN; PATHWAY; MICRORNA; APC;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cervical cancer (CC) is among the leading causes of cancer-associated mortality in women worldwide; yet the molecular regulators involved in its progression are unclear. This study found that miR-182 was overexpressed in CC tissues when compared with adjacent normal tissues. Moreover, it found that miR-182 expression was significantly positively correlated with distant metastasis in patients with CC. Interestingly, in vitro experiments showed that overexpression and inhibition of miR-182 promoted and suppressed the growth of CC cells, respectively. The tumorpromoting effects of miR-182 on CC progression were achieved via the Wnt/beta-catenin axis and its downstream genes. Thus, this study revealed the potential of miR-182/beta-catenin as an effective new target for CC treatment.
引用
收藏
页码：3591 / 3598
页数：8
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