Isolated Limb Perfusion for Extremity Soft Tissue Sarcoma and Malignant Melanoma

被引：0

作者：

Russell, Michael ^{[1
]}

Wilkinson, Michelle ^{[1
]}

Hayes, Andrew ^{[1
,2
]}

机构：

[1] Royal Marsden Hosp NHS Fdn Trust, Sarcoma & Melanoma Unit, London, England

[2] Inst Canc Res, 237 Fulham Rd, London SW3 6JB, England

来源：

INDIAN JOURNAL OF SURGICAL ONCOLOGY | 2024年 / 15卷 / 03期

关键词：

Isolated limb perfusion; Chemotherapy; Extremity soft tissue sarcoma; TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; STAGE-III; TNF-ALPHA; POSTOPERATIVE RADIOTHERAPY; OPEN-LABEL; MELPHALAN; MULTICENTER; INFUSION; CHEMOTHERAPY;

D O I：

10.1007/s13193-024-01920-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Isolated limb perfusion (ILP) is a regional chemotherapy technique used in the treatment of locally advanced or unresectable extremity soft tissue sarcoma (ESTS) or malignant melanoma (MM) of the limbs. It allows for high concentrations of chemotherapeutic agents to be perfused in the limb while minimising the risk of systemic side-effects. While the technique has been utilized for decades, the role of ILP has evolved as other treatment strategies have become available. Current indications for ILP in sarcoma include induction in unresectable ESTS to allow for future definitive limb preservation procedures as well as definitive treatment of unresectable, multifocal ESTS. In MM, ILP is typically used in unresectable in-transit melanoma, and rarely as an alternative to amputation in bulky, symptomatic extremity disease. This review seeks to summarise the current evidence base and indications for ILP as well as present some technical insights from a high-volume United Kingdom (UK) unit.

引用

页码：499 / 508

页数：10

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