Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery

被引:1
作者
Tichy, Johanna [1 ]
Pajenda, Sahra [2 ]
Bernardi, Martin H. [1 ]
Wagner, Ludwig [2 ]
Ryz, Sylvia [1 ]
Aiad, Monika [2 ]
Gerges, Daniela [2 ]
Schmidt, Alice [2 ]
Lassnigg, Andrea [1 ]
Herkner, Harald [3 ]
Winnicki, Wolfgang [2 ]
Maringhini, Silvio
机构
[1] Med Univ Vienna, Dept Anesthesiol Intens Care Med & Pain Med, Div Cardiac Thorac Vasc Anesthesia & Intens Care M, A-1090 Vienna, Austria
[2] Med Univ Vienna, Dept Internal Med 3, Div Nephrol & Dialysis, A-1090 Vienna, Austria
[3] Med Univ Vienna, Dept Emergency Med, A-1090 Vienna, Austria
关键词
acute kidney injury; biomarker; cardiac surgery; collectrin; ACUTE-RENAL-FAILURE; RECOVERY; MARKER; MICE; AKI;
D O I
10.3390/biomedicines11123244
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Early detection of acute kidney injury (AKI) is crucial for timely intervention and improved patient outcomes after cardiac surgery. This study aimed to evaluate the potential of urinary collectrin as a novel biomarker for AKI in this patient population. Methods: In this prospective, observational cohort study, 63 patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB) were studied at the Medical University of Vienna between 2016 and 2018. We collected urine samples prospectively at four perioperative time points, and urinary collectrin was measured using an enzyme-linked immunosorbent assay. Patients were divided into two groups, AKI and non-AKI, defined by Kidney Disease: Improving Global Outcomes Guidelines, and differences between groups were analyzed. Results: Postoperative AKI was found in 19 (30%) patients. Urine sample analysis revealed an inverse correlation between urinary collectrin and creatinine and AKI stages, as well as significant changes in collectrin levels during the perioperative course. Baseline collectrin levels were 5050 +/- 3294 pg/mL, decreased after the start of CPB, reached their nadir at the end of surgery, and began to recover slightly on postoperative day (POD) 1. The most effective timepoint for distinguishing between AKI and non-AKI patients based on collectrin levels was POD 1, with collectrin levels of 2190 +/- 3728 pg/mL in AKI patients and 3768 +/- 3435 pg/mL in non-AKI patients (p = 0.01). Conclusions: Urinary collectrin shows promise as a novel biomarker for the early detection of AKI in patients undergoing cardiac surgery on CPB. Its dynamic changes throughout the perioperative period, especially on POD 1, provide valuable insights for timely diagnosis and intervention. Further research and validation studies are needed to confirm its clinical usefulness and potential impact on patient outcomes.
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页数:10
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