Identification and Validation of Ferroptosis-Related LncRNAs Signature as a Novel Prognostic Model for Chronic Lymphocytic Leukemia

被引：2

作者：

Xu, Zhangdi ^{[1
,2
,3
]}

Pan, Bihui ^{[1
,2
,3
]}

Li, Yue ^{[1
,2
,3
]}

Xia, Yi ^{[1
,2
,3
]}

Liang, Jinhua ^{[1
,2
,3
]}

Kong, Yilin ^{[1
,2
,3
]}

Zhang, Xinyu ^{[1
,2
,3
]}

Tang, Jing ^{[1
,2
,3
]}

Wang, Li ^{[1
,2
,3
]}

Li, Jianyong ^{[1
,2
,3
]}

Xu, Wei ^{[1
,2
,3
]}

Wu, Jiazhu ^{[1
,2
,3
]}

机构：

[1] Nanjing Med Univ, Jiangsu Prov Hosp, Dept Hematol, Affiliated Hosp 1, Nanjing 210029, Peoples R China

[2] Nanjing Med Univ, Key Lab Hematol, Nanjing, Peoples R China

[3] Collaborat Innovat Ctr Canc Personalized Med, Nanjing, Peoples R China

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2023年 / 16卷

基金：

中国国家自然科学基金;

关键词：

chronic lymphocytic leukemia; ferroptosis; long non -coding RNAs; prognosis; immune infiltration; CLL-IPI; INDEX;

D O I：

10.2147/IJGM.S399629

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Chronic lymphocytic leukemia (CLL) is a subtype of B-cell malignancy with high heterogeneity. Ferroptosis is a novel cell death induced by iron and lipid peroxidation and exhibits prognostic value in many cancers. Emerging studies on long non-coding RNAs (lncRNAs) and ferroptosis reveal the unique value in tumorigenesis. However, the prognostic value of ferroptosis-related lncRNAs (FRLs) remains unclear in CLL. Aim: We aimed to construct a FRLs risk model to predict prognosis and improve prognostic stratification for clinical practice. Methods: RNA-sequencing data and clinical characteristics of CLL patients were downloaded from the GEO database. Based on ferroptosis-related genes from FerrDb database, differentially expressed FRLs with prognostic significance were identified and used to generate the risk model. The capability of the risk model was assessed and evaluated. GO and KEGG analyses were performed to confirm biological roles and potential pathways. Results: A novel ferroptosis-related lncRNAs prognostic score (FPS) model containing six FRLs (PRKCQ, TRG.AS1, LNC00467, LNC01096, PCAT6 and SBF2.AS1) was identified. Patients in the training and validation cohort were evenly divided into high- and low-risk groups. Our results indicated that patients in the high-risk group had worse survival than those in the low-risk group. Functional enrichment analyses showed that the differently expressed genes (DEGs) between the two groups were enriched in the chemokine signaling pathway, hematopoietic cell lineage, T cell differentiation, TCR pathway and NF-kappa B pathway. Moreover, significant differences in immune cell infiltration were also observed. Surprisingly, FPS was proved to be an independent prognostic indicator for OS. Conclusion: We established and evaluated a novel prognostic risk model with 6 FRLs that could predict prognosis accurately and describe the distinct immune infiltration in CLL.

引用

页码：1541 / 1553

页数：13

共 44 条

[1] The road to chemotherapy-free treatment in chronic lymphocytic leukaemia [J].

Albiol, Nil ;

Arguello-Tomas, Miguel ;

Moreno, Carol .

CURRENT OPINION IN ONCOLOGY, 2021, 33 (06) :670-680

[2]

BERGSAGEL DE, 1967, CAN MED ASSOC J, V96, P1615

[3] APR-246 induces early cell death by ferroptosis in acute myeloid leukemia [J].

Birsen, Rudy ;

Larrue, Clement ;

Decroocq, Justine ;

Johnson, Natacha ;

Guiraud, Nathan ;

Gotanegre, Mathilde ;

Cantero-Aguilar, Lilia ;

Grignano, Eric ;

Huynh, Tony ;

Fontenay, Michaela ;

Kosmider, Olivier ;

Mayeux, Patrick ;

Chapuis, Nicolas ;

Sarry, Jean Emmanuel ;

Tamburini, Jerome ;

Bouscary, Didier .

HAEMATOLOGICA, 2022, 107 (02) :403-416

[4] LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer [J].

Bo, Hao ;

Zhang, Wancong ;

Zhong, Xiaoping ;

Chen, Jiasheng ;

Liu, Yang ;

Cheong, Kit-Leong ;

Fan, Pengju ;

Tang, Shijie .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021

[5] Chronic lymphocytic leukaemia: from genetics to treatment [J].

Bosch, Francesc ;

Dalla-Favera, Riccardo .

NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (11) :684-701

[6] Ferroptosis-Related Gene Signature: A New Method for Personalized Risk Assessment in Patients with Diffuse Large B-Cell Lymphoma [J].

Chen, Huan ;

He, Yizi ;

Pan, Tao ;

Zeng, Ruolan ;

Li, Yajun ;

Chen, Siwei ;

Li, Yufeng ;

Xiao, Ling ;

Zhou, Hui .

PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2021, 14 :609-619

[7]

Chen YY, 2021, CELL SIGNAL, V88, DOI [10.1016/j.cellsig.2021.110167, 10.1007/978-981-15-8411-4_21]

[8] Context-dependent regulation of follicular helper T cell survival [J].

Chen, Zhian ;

Wang, Naiqi ;

Yao, Yin ;

Yu, Di .

TRENDS IN IMMUNOLOGY, 2022, 43 (04) :309-321

[9] Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein [J].

Dai, Enyong ;

Han, Leng ;

Liu, Jiao ;

Xie, Yangchun ;

Kroemer, Guido ;

Klionsky, Daniel J. ;

Zeh, Herbert J. ;

Kang, Rui ;

Wang, Jing ;

Tang, Daolin .

AUTOPHAGY, 2020, 16 (11) :2069-2083

[10] Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death [J].

Dixon, Scott J. ;

Lemberg, Kathryn M. ;

Lamprecht, Michael R. ;

Skouta, Rachid ;

Zaitsev, Eleina M. ;

Gleason, Caroline E. ;

Patel, Darpan N. ;

Bauer, Andras J. ;

Cantley, Alexandra M. ;

Yang, Wan Seok ;

Morrison, Barclay, III ;

Stockwell, Brent R. .

CELL, 2012, 149 (05) :1060-1072

← 1 2 3 4 5 →