Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer

被引：5
作者：
Zhu, Ziwei [1 ]
Peng, Qian [2 ]
Duan, Xingmei [3 ]
Li, Jie [4 ,5 ,6 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou, Peoples R China
[2] Univ Elect Sci & Technol China, Affiliated Canc Hosp,Sichuan Canc Ctr, Radiat Oncol Key Lab Sichuan Prov,Dept Radiat Onco, Sichuan Clin Res Ctr Canc,Sichuan Canc Hosp & Inst, Chengdu, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sch Med, Dept Pharm,Personalized Drug Therapy Key Lab Sichu, Chengdu, Peoples R China
[4] Southwest Med Univ China, Sch Med, Luzhou, Peoples R China
[5] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Affiliated Canc Hosp,Sichuan Canc Ctr, Sichuan Clin Res Ctr Canc,Dept Radiotherapy,Radiat, Chengdu, Peoples R China
[6] Southwest Med Univ China, Sch Med, Luzhou, Sichuan, Peoples R China
来源：
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2024年 / 44卷 / 04期
关键词：
immunotherapy; IL-12; colorectal cancer; antitumor therapy; REGULATORY T-CELLS; RECOMBINANT HUMAN INTERLEUKIN-12; IL-12; FAMILY; INTERFERON-GAMMA; GENE-THERAPY; TYROSINE PHOSPHORYLATION; ANTITUMOR-ACTIVITY; IMMUNE-RESPONSES; ENCODING IL-12; TH1; CELLS;
D O I：
10.1089/jir.2023.0190
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin 12 (IL-12) is a heterodimer consisting of 2 subunits, p35 and p40, with unique associations and interacting functions with its family members. IL-12 is one of the most important cytokines regulating the immune system response and is integral to adaptive immunity. IL-12 has shown marked therapeutic potential in a variety of tumor types. This review therefore summarizes the characteristics of IL-12 and its application in tumor treatment, focusing on its antitumor effects in colorectal cancer (CRC) and potential radiosensitization mechanisms. We aim to provide a current reference for IL-12 and other potential CRC treatment strategies.
引用
收藏
页码：158 / 169
页数：12
相关论文
共 124 条
[1]   T-cell control of IL-12p75 production [J].
Abdi, K. ;
Singh, N. ;
Matzinger, P. .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2006, 64 (02) :83-92
[2]   Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma [J].
Algazi, Alain P. ;
Twitty, Christopher G. ;
Tsai, Katy K. ;
Le, Mai ;
Pierce, Robert ;
Browning, Erica ;
Hermiz, Reneta ;
Canton, David A. ;
Bannavong, Donna ;
Oglesby, Arielle ;
Francisco, Murray ;
Fong, Lawrence ;
Pittet, Mikael J. ;
Arlauckas, Sean P. ;
Garris, Christopher ;
Levine, Lauren P. ;
Bifulco, Carlos ;
Ballesteros-Merino, Carmen ;
Bhatia, Shailender ;
Gargosky, Sharron ;
Andtbacka, Robert H. I. ;
Fox, Bernard A. ;
Rosenblum, Michael D. ;
Daud, Adil I. .
CLINICAL CANCER RESEARCH, 2020, 26 (12) :2827-2837
[3]   Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer [J].
Anwer, K. ;
Barnes, M. N. ;
Fewell, J. ;
Lewis, D. H. ;
Alvarez, R. D. .
GENE THERAPY, 2010, 17 (03) :360-369
[4]   Global patterns and trends in colorectal cancer incidence and mortality [J].
Arnold, Melina ;
Sierra, Monica S. ;
Laversanne, Mathieu ;
Soerjomataram, Isabelle ;
Jemal, Ahmedin ;
Bray, Freddie .
GUT, 2017, 66 (04) :683-691
[5]   IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection [J].
Ashman, Robert B. ;
Vijayan, Dipti ;
Wells, Christine A. .
CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011,
[6]   INTERLEUKIN-12 (IL-12) INDUCES TYROSINE PHOSPHORYLATION OF JAK2 AND TYK2 - DIFFERENTIAL USE OF JANUS FAMILY TYROSINE KINASES BY IL-2 AND IL-12 [J].
BACON, CM ;
MCVICAR, DW ;
ORTALDO, JR ;
REES, RC ;
O'SHEA, JJ ;
JOHNSTON, JA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :399-404
[7]   INTERLEUKIN-12 INDUCES TYROSINE PHOSPHORYLATION AND ACTIVATION OF STAT4 IN HUMAN-LYMPHOCYTES [J].
BACON, CM ;
PETRICOIN, EF ;
ORTALDO, JR ;
REES, RC ;
LARNER, AC ;
JOHNSTON, JA ;
O'SHEA, JJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7307-7311
[8]   Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27 [J].
Beadling, C ;
Slifka, MK .
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2006, 54 (01) :15-24
[9]   IL-12 FAMILY CYTOKINES: GENERAL CHARACTERISTICS, PATHOGENIC MICROORGANISMS, RECEPTORS, AND SIGNALLING PATHWAYS [J].
Behzadi, Payam ;
Behzadi, Elham ;
Ranjbar, Reza .
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2016, 63 (01) :1-25
[10]   Th17: the third member of the effector T cell trilogy [J].
Bettelli, Estelle ;
Korn, Thomas ;
Kuchroo, Vijay K. .
CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (06) :652-657
12345678910