T cell receptor sequences are the dominant factor contributing to the phenotype of CD8+T cells with specificities against immunogenic viral antigens

被引:6
作者
Chen, Daniel G. [1 ,2 ,3 ]
Xie, Jingyi [1 ,4 ]
Su, Yapeng [2 ,3 ]
Heath, James R. [1 ,5 ]
机构
[1] Inst Syst Biol, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA
[3] Fred Hutchinson Canc Res Ctr, Program Immunol, Clin Res Div, Seattle, WA 98109 USA
[4] Univ Washington, Mol Engn & Sci Inst, Seattle, WA 98105 USA
[5] Univ Washington, Dept Bioengn, Seattle, WA 98105 USA
来源
CELL REPORTS | 2023年 / 42卷 / 11期
关键词
EFFECTOR; ACTIVATION; EXPRESSION; RESPONSES; IL-7; DIFFERENTIATION; PROLIFERATION; REPERTOIRE; METABOLISM; INFECTION;
D O I
10.1016/j.celrep.2023.113279
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Antigen-specific CD8+ T cells mediate pathogen clearance. T cell phenotype is influenced by T cell receptor (TCR) sequences and environmental signals. Quantitative comparisons of these factors in human disease, while challenging to obtain, can provide foundational insights into basic T cell biology. Here, we investigate the phenotype kinetics of 679 CD8+ T cell clonotypes, each with specificity against one of three immunogenic viral antigens. Data were collected from a longitudinal study of 68 COVID-19 patients with antigens from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cytomegalovirus (CMV), and influenza. Each antigen is associated with a different type of immune activation during COVID-19. We find TCR sequence to be by far the most important factor in shaping T cell phenotype and persistence for populations specific to any of these antigens. Our work demonstrates the important relationship between TCR sequence and T cell phenotype and persistence and helps explain why T cell phenotype often appears to be determined early in an infection.
引用
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页数:20
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