Considering molecular alterations as pan-cancer tissue-agnostic targets

被引：9

作者：

Adashek, Jacob J. ^{[1
]}

Kato, Shumei ^{[2
]}

Sicklick, Jason K. ^{[2
,3
,4
]}

Lippman, Scott M. ^{[2
]}

Kurzrock, Razelle ^{[5
,6
,7
]}

机构：

[1] Johns Hopkins Univ Hosp, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21287 USA

[2] UC San Diego Moores Canc Ctr, Ctr Personalized Canc Therapy, La Jolla, CA USA

[3] Univ Calif San Diego, Dept Surg, Div Surg Oncol, UC San Diego Hlth, La Jolla, CA USA

[4] Univ Calif San Diego, Dept Pharmacol, UC San Diego Hlth, San Diego, CA USA

[5] Med Coll Wisconsin, Genom Sci & Precis Med Ctr, Milwaukee, WI 53226 USA

[6] WIN Consortium, Paris, France

[7] Univ Nebraska, Lincoln, NE 68588 USA

来源：

NATURE CANCER | 2023年 / 4卷 / 12期

基金：

美国国家卫生研究院;

关键词：

BRAF;

D O I：

10.1038/s43018-023-00676-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Owing to high response rates, the Food and Drug Administration has approved both gene- and immune-targeted drugs for tumor-agnostic, genomic biomarker-based indications, for lethal solid and blood cancers. We posit that current data support tissue-agnostic activity as a paradigm, rather than an exception to the rule.

引用

页码：1622 / 1626

页数：5

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