Homocysteine and Parkinson's disease

被引：21
作者：
Zhou, Lingyan [1 ]
机构：
[1] Shandong First Med Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Shandong, Peoples R China
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2024年 / 30卷 / 02期
关键词：
homocysteine; hyperohomocysteinemia; Parkinson's disease; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; PLASMA HOMOCYSTEINE; COGNITIVE FUNCTION; FOLATE-DEFICIENCY; DNA METHYLATION; RAT MODEL; METABOLISM; HYPERHOMOCYSTEINEMIA; METHIONINE;
D O I：
10.1111/cns.14420
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Homocysteine (Hcy) is an important metabolite in methionine metabolism. When the metabolic pathway of homocysteine is abnormal, it will accumulate in the body and eventually lead to hyperhomocysteinemia. In recent years, many studies have found that hyperhomocysteinemia is related to the occurrence and development of Parkinson's disease. This study reviews the roles of homocysteine in the pathogenesis of Parkinson's disease and illustrates the harmful effects of hyperhomocysteinemia on Parkinson's disease.
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页数：7
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