The mediating role of quality of life on depression and medication adherence among patients with type 2 diabetes mellitus: A cross-sectional study

被引：3

作者：

Yorke, Ernest ^{[1
,8
]}

Boima, Vincent ^{[1
]}

Ganu, Vincent ^{[2
]}

Tetteh, John ^{[3
]}

Twumasi, Louisa ^{[4
]}

Ekem-Ferguson, George ^{[4
,5
,6
]}

Kretchy, Irene ^{[4
]}

Mate-Kole, Christopher C. ^{[4
,6
,7
]}

机构：

[1] Univ Ghana, Med Sch, Coll Hlth Sci, Dept Med & Therapeut, Accra, Ghana

[2] Korle Bu Teaching Hosp, Dept Med, Cardiothorac Unit, Accra, Ghana

[3] Univ Ghana, Med Sch, Coll Hlth Sci, Dept Community Hlth, Accra, Ghana

[4] Univ Ghana, Dept Psychol, Accra, Ghana

[5] Korle Bu Teaching Hosp, Natl Cardiothorac Ctr, Accra, Ghana

[6] Univ Ghana, Coll Hlth Sci, Med Sch, Dept Psychiat, Accra, Ghana

[7] Univ Ghana, Coll Humanities, Ctr Ageing Studies, Legon, Ghana

[8] Univ Ghana, Coll Hlth Sci, Sch Med & Dent, Dept Med & Therapeut, Legon, Accra, Ghana

来源：

HEALTH SCIENCE REPORTS | 2023年 / 6卷 / 09期

关键词：

depression; medication adherence; quality of life; type; 2; diabetes; ASSOCIATION; PREVALENCE; MORTALITY; DISTRESS;

D O I：

10.1002/hsr2.1539

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background and Aim: Patients living with diabetes mellitus have a high burden of psychological distress such as depression and anxiety as well as impaired quality of life, which may negatively impact their adherence to medications, glucose control, and health-related costs. This study assessed the impact of quality of life and depression on medication adherence among patients with type 2 diabetes (type 2 diabetes mellitus [T2DM]) in a tertiary care setting in Ghana Methods: The study was a cross-sectional study involving 238 patients with diabetes aged 18 years and above. Validated tools were used to assess medication adherence, depressive symptoms, and quality of life. Structural Equation Modeling was adopted to examine the mediation effect of quality of life on the relationship between depression and medication adherence among participants. Results: The mean age of the participants was 58.82 +/- 13.49, and 169 (71.0%) out of a total of 238 respondents were females. Depression had a significant direct relationship with the quality of life of respondents [a beta (95% confidence interval, CI) = -0.20 (-0.03, -0.00), p < 0.05; -0.21 (-0.41, -0.01) p < 0.05, respectively] and indirect relationship with quality of life [a beta (95% CI) = -0.01 (-0.02, -0.004) p < 0.001]. Educational status and religion both showed a significant indirect relationship with quality of life [a beta (95% CI) = 0.06 (0.07, 0.12), p < 0.05; 0.18 (0.01, 0.35) p < 0.05, respectively]. The mediating effect of quality of life on the relationship between depression and medication adherence was significant (Sobel = -3.19, p < 0.001). Conclusion: Depression, medication adherence, and quality of life were higher among older adults with T2DM. Depression was also found to have a strong negative association with both medication adherence and quality of life. Interventions to screen for depression and to improve the quality of life in patients living with diabetes are also recommended and this should go beyond the provision of standard treatments to explore further the mechanisms of this relationships.

引用

页数：12

共 47 条

[1] Medication adherence and self-care behaviours among patients with type 2 diabetes mellitus in Ghana [J].