Pharmacological pain management in cancer patients

被引：0

作者：

Muetherig, Anke ^{[1
,2
]}

Scheffler, Gesine ^{[3
]}

Schuler, Ulrich S. S. ^{[1
,2
]}

机构：

[1] Univ Klinikum Carl Gustav Carus Dresden, Palliativ Zentrum, Fetscherstr 74, D-01307 Dresden, Germany

[2] Univ Klinikum Carl Gustav Carus Dresden, Med Klin & Poliklin 1, D-01307 Dresden, Germany

[3] Univ Klinikum Carl Gustav Carus Dresden, Klin Apotheke, Dresden, Germany

来源：

ONKOLOGIE | 2023年 / 29卷 / 08期

关键词：

Cancer pain; Analgesics; opioid; Morphine; Acetaminophen; Cannabinoids; ANALGESIC LADDER; MORPHINE; VALIDATION; METHADONE; EFFICACY; OPIOIDS; TRIAL;

D O I：

10.1007/s00761-023-01394-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pharmacological pain therapy in cancer patients is based on guideline recommendations, which, however, do not fully coincide in all aspects due to varying weighting of evidence. The present article discusses current issues including the decreasing significance of the World Health Organization (WHO) analgesic ladder, with its distinction between step 2 and 3 being increasingly questioned. Risks of nonopioid analgesics such as paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs), particularly in older populations, are discussed. Paracetamol may potentially reduce the effectiveness of immunotherapies. Aspects of administering analgesics via a feeding tube are considered. Recommendations for the treatment of episodic pain, transitioning between different opioids, and some relevant interactions are also discussed.

引用

页码：727 / 736

页数：10

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