Molecular and metabolic heterogeneity of astrocytes and microglia

被引：65

作者：

Hasel, Philip ^{[1
]}

Aisenberg, William H. ^{[2
]}

Bennett, F. Chris ^{[2
,3
]}

Liddelow, Shane A. ^{[1
,4
,5
,6
]}

机构：

[1] NYU, Grossman Sch Med, Neurosci Inst, New York, NY 10016 USA

[2] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA

[4] NYU, Grossman Sch Med, Dept Neurosci & Physiol, New York, NY 10016 USA

[5] NYU, Grossman Sch Med, Dept Ophthalmol, New York, NY 10016 USA

[6] NYU, Grossman Sch Med, Parekh Ctr Interdisciplinary Neurol, New York, NY 10016 USA

来源：

CELL METABOLISM | 2023年 / 35卷 / 04期

关键词：

IN-VITRO; MONOCARBOXYLATE TRANSPORTERS; ASTROGLIAL CELLS; BRAIN; MOUSE; CHOLESTEROL; NEURONS; EXPRESSION; CLEARANCE; REVEALS;

D O I：

10.1016/j.cmet.2023.03.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Astrocytes and microglia are central players in a myriad of processes in the healthy and diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell types contributes to pathology in many if not all neuroinflammatory and neurodegenerative diseases. Recent advancements in integrative multimodal sequencing techniques have begun to highlight how heterogeneous both cell types are and the importance of metabolism to their regulation. We discuss here the transcriptomic, metabolic, and func-tional heterogeneity of astrocytes and microglia and highlight their interaction in health and disease.

引用

页码：555 / 570

页数：16

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