Synthesis and Biological Activity Evaluations of Green ZnO-Decorated Acid-Activated Bentonite-Mediated Curcumin Extract (ZnO@CU/BE) as Antioxidant and Antidiabetic Agents

被引:12
作者
Rudayni, Hassan Ahmed [1 ]
Shemy, Marwa H. [2 ,3 ]
Aladwani, Malak [1 ]
Alneghery, Lina M. [1 ]
Abu-Taweel, Gasem M. [4 ]
Allam, Ahmed A. [5 ]
Abukhadra, Mostafa R. [3 ,6 ]
Bellucci, Stefano [7 ]
机构
[1] Imam Muhammad Bin Saud Islamic Univ, Coll Sci, Dept Biol, Riyadh 11623, Saudi Arabia
[2] Beni Suef Univ, Fac Sci, Chem Dept, Bani Suwayf 65211, Egypt
[3] Beni Suef Univ, Fac Sci, Geol Dept, Mat Technol & Their Applicat Lab, Bani Suwayf 65214, Egypt
[4] Jazan Univ, Coll Sci, Dept Biol, POB 2079, Jazan 45142, Saudi Arabia
[5] Beni Suef Univ, Fac Sci, Zool Dept, Bani Suwayf 62514, Egypt
[6] Beni Suef Univ, Fac Sci, Geol Dept, Bani Suwayf 65214, Egypt
[7] INFN Lab Nazl Frascati, Via E Fermi 54, I-00044 Frascati, Italy
关键词
bentonite; ZnO; curcumin; composite; antioxidant; antidiabetes; DIABETES-MELLITUS; ALPHA-GLUCOSIDASE; ZINC-OXIDE; NANOPARTICLES; AMYLASE;
D O I
10.3390/jfb14040198
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Green ZnO-decorated acid-activated bentonite-mediated curcumin extract (ZnO@CU/BE) was prepared as a multifunctional antioxidant and antidiabetic agent based on the extract of curcumin, which was used as a reducing and capping reagent. ZnO@CU/BE showed notably enhanced antioxidant properties against nitric oxide (88.6 +/- 1.58%), 1,1-diphenyl-2-picrylhydrazil (90.2 +/- 1.76%), 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (87.3 +/- 1.61%), and superoxide (39.5 +/- 1.12%) radicals. These percentages are higher than the reported values of ascorbic acid as a standard and the integrated components of the structure (CU, BE/CU, and ZnO). This signifies the impact of the bentonite substrate on enhancing the solubility, stability, dispersion, and release rate of the intercalated curcumin-based phytochemicals, in addition to enhancing the exposure interface of ZnO nanoparticles. Therefore, effective antidiabetic properties were observed, with significant inhibition effects on porcine pancreatic alpha-amylase (76.8 +/- 1.87%), murine pancreatic alpha-amylase (56.5 +/- 1.67%), pancreatic alpha-glucosidase (96.5 +/- 1.07%), murine intestinal alpha-glucosidase (92.5 +/- 1.10%), and amyloglucosidase (93.7 +/- 1.55%) enzymes. These values are higher than those determined using commercial miglitol and are close to the values measured using acarbose. Hence, the structure can be applied as an antioxidant and antidiabetic agent.
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页数:21
相关论文
共 72 条
[1]   Synthesis and Characterization of Green ZnO@polynaniline/Bentonite Tripartite Structure (G.Zn@PN/BE) as Adsorbent for As (V) Ions: Integration, Steric, and Energetic Properties [J].
Abdel Salam, Mohamed ;
Mokhtar, Mohamed ;
Albukhari, Soha M. ;
Baamer, Doaa F. ;
Palmisano, Leonardo ;
Jaremko, Mariusz ;
Abukhadra, Mostafa R. .
POLYMERS, 2022, 14 (12)
[2]   Enhanced decontamination of Levofloxacin residuals from water using recycled glass based a green zinc oxide/mesoporous silica nanocomposite; adsorption and advanced oxidation studies [J].
Abukhadra, Mostafa R. ;
AlHammadi, Ali A. ;
Khim, Jong Seong ;
Ajarem, Jamaan S. ;
Allam, Ahmed A. .
JOURNAL OF CLEANER PRODUCTION, 2022, 356
[3]   Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber [J].
Abukhadra, Mostafa R. ;
Adlii, Alyaa ;
El-Sherbeeny, Ahmed M. ;
Soliman, Ahmed Tawhid Ahmed ;
Abd Elgawad, Abd Elatty E. .
JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2020, 273
[4]   Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin- Induced Diabetic Rats [J].
Alkaladi, Ali ;
Abdelazim, Aaser Mohamed ;
Afifi, Mohamed .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (02) :2015-2023
[5]  
[Anonymous], 2013, The Pharma Innovation
[6]  
Ansari Anam, 2022, Steroids, V188, P109113, DOI 10.1016/j.steroids.2022.109113
[7]   A comprehensive study on antidiabetic and antibacterial activities of ZnO nanoparticles biosynthesized using Silybum marianum L seed extract [J].
Arvanag, Farid Mohammadi ;
Bayrami, Abolfazl ;
Habibi-Yangjeh, Aziz ;
Pouran, Shima Rahim .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 97 :397-405
[8]   Surface defect rich ZnO quantum dots as antioxidants inhibiting α-amylase and α-glucosidase: a potential anti-diabetic nanomedicine [J].
Asok, Adersh ;
Ghosh, Sougata ;
More, Piyush A. ;
Chopade, Balu A. ;
Gandhi, Mayuri N. ;
Kulkarni, Ajit R. .
JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (22) :4597-4606
[9]   Unfolding Nrf2 in diabetes mellitus [J].
Behl, Tapan ;
Kaur, Ishnoor ;
Sehgal, Aayush ;
Sharma, Eshita ;
Kumar, Arun ;
Grover, Madhuri ;
Bungau, Simona .
MOLECULAR BIOLOGY REPORTS, 2021, 48 (01) :927-939
[10]   Study of the antioxidant activity of Pistacia atlantica Desf. Gall extracts and evaluation of the responsible compounds [J].
Ben Ahmed, Ziyad ;
Hefied, Fatiha ;
Yousfi, Mohamed ;
Demeyer, Kristiaan ;
Vander Heyden, Yvan .
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2022, 100