Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

被引：29
作者：
Madamsetty, Vijay Sagar [1 ,2 ]
Vazifehdoost, Maryam [3 ]
Alhashemi, Samira Hossaini [4 ]
Davoudi, Hesam [5 ]
Zarrabi, Ali [6 ]
Dehshahri, Ali [7 ]
Fekri, Hojjat Samareh [8 ]
Mohammadinejad, Reza [9 ]
Thakur, Vijay Kumar [10 ,11 ]
机构：
[1] Mayo Clin, Dept Biochem & Mol Biol, Coll Med & Sci, Jacksonville, FL 32224 USA
[2] CSL Seqirus, Waltham, MA USA
[3] Kerman Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Kerman 6718773654, Iran
[4] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz 7146864685, Iran
[5] Univ Zanjan, Fac Sci, Dept Biol, Zanjan 4537138111, Iran
[6] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34396 Istanbul, Turkiye
[7] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Shiraz 7146864685, Iran
[8] Kerman Univ Med Sci, Student Res Comm, Kerman 7619813159, Iran
[9] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman 7619813159, Iran
[10] Scotlands Rural Coll SRUC, Biorefining & Adv Mat Res Ctr, Edinburgh EH9 3JG, Scotland
[11] Univ Petr & Energy Studies UPES, Sch Engn, Dehra Dun 248007, Uttarakhand, India
来源：
ACS OMEGA | 2023年 / 8卷 / 10期
基金：
英国科研创新办公室;
关键词：
IMPROVING ANTITUMOR-ACTIVITY; EFFECTIVELY KILL BACTERIA; CELLULOSE-BASED HYDROGELS; DRUG-DELIVERY SYSTEMS; SITU-FORMING HYDROGEL; IN-VITRO; BETA-CYCLODEXTRIN; SUSTAINED-RELEASE; LOADED HYDROGEL; CONJUGATED POLYETHYLENIMINE;
D O I：
10.1021/acsomega.2c07062
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.
引用
收藏
页码：8960 / 8976
页数：17
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