A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans

被引：41

作者：

Topalovic, Uros ^{[1
,2
]}

Barclay, Sam ^{[1
]}

Ling, Chenkai ^{[1
]}

Alzuhair, Ahmed ^{[3
]}

Yu, Wenhao ^{[1
]}

Hokhikyan, Vahagn ^{[1
]}

Chandrakumar, Hariprasad ^{[1
]}

Rozgic, Dejan ^{[1
]}

Jiang, Wenlong ^{[1
]}

Basir-Kazeruni, Sina ^{[1
]}

Maoz, Sabrina L. L. ^{[4
,5
]}

Inman, Cory S. S. ^{[6
]}

Stangl, Matthias ^{[2
]}

Gill, Jay ^{[2
,5
]}

Bari, Ausaf ^{[7
]}

Fallah, Aria ^{[7
]}

Eliashiv, Dawn ^{[8
]}

Pouratian, Nader ^{[9
]}

Fried, Itzhak ^{[2
,7
]}

Suthana, Nanthia ^{[2
,4
,7
,10
]}

Markovic, Dejan ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Elect & Comp Engn, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Jane & Terry Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[3] King Saud Univ, Dept Elect Engn, Riyadh, Saudi Arabia

[4] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Med Scientist Training Program, Los Angeles, CA USA

[6] Univ Utah, Dept Psychol, Salt Lake City, UT USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA

[8] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA USA

[9] UT Southwestern Med Ctr, Dept Neurol Surg, Dallas, TX USA

[10] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

来源：

NATURE NEUROSCIENCE | 2023年 / 26卷 / 03期

关键词：

DEEP-BRAIN-STIMULATION; HUMAN-MEMORY; EEG; DYNAMICS;

D O I：

10.1038/s41593-023-01260-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Neuro-stack is a wearable platform for recording from single neurons in freely moving humans. It also allows for personalized stimulation during real-time decoding of neural activity. Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.

引用

页码：517 / +

页数：30

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