Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate

被引：0

作者：

Micheletti, Gabriele ^{[1
]}

Boga, Carla ^{[1
]}

机构：

[1] Alma Mater Studiorum Univ Bologna, Dept Ind Chem Toso Montanari, Viale Risorgimento 4, I-40136 Bologna, Italy

来源：

MOLBANK | 2023年 / 2023卷 / 01期

关键词：

indole; azelaic acid; acylation; Friedel-Crafts;

D O I：

10.3390/M1579

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate was synthesized using Friedel-Crafts acylation between N-methyl indole and methyl 9-chloro-9-oxononanoate. The structure of the newly synthesized compound was elucidated using H-1-NMR, C-13-NMR, NOESY-1D, ESI-MS, FT-IR, and UV-Vis spectroscopy.

引用

页数：3

共 9 条

[1] New Hybrids with 2-aminobenzothiazole and Azelayl Scaffolds: Synthesis, Molecular Docking and Biological Evaluation [J].

Boga, Carla ;

Micheletti, Gabriele ;

Orlando, Isabel ;

Strocchi, Elena ;

Vitali, Beatrice ;

Verardi, Laura ;

Sartor, Giorgio ;

Calonghi, Natalia .

CURRENT ORGANIC CHEMISTRY, 2018, 22 (16) :1649-1660

[2]

Fairbrother F., 1941, T FARADAY SOC, V37, P763, DOI DOI 10.1039/TF941370763B

[3]

Friedel C., 1877, Compt. Rend, V84, P1450

[4] A brief review of the biological potential of indole derivatives [J].

Kumar, Sunil ;

Ritika .

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 6 (01)

[5] Biocatalytic Friedel-Crafts Reactions [J].

Leveson-Gower, Reuben B. ;

Roelfes, Gerard .

CHEMCATCHEM, 2022, 14 (18)

[6] New Friedel-Crafts strategy for preparing 3-acylindoles [J].

Li, Lian-Hua ;

Niu, Zhi-Jie ;

Liang, Yong-Min .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 16 (42) :7792-7796

[7] Synthesis of Novel Structural Hybrids between Aza-Heterocycles and Azelaic Acid Moiety with a Specific Activity on Osteosarcoma Cells [J].

Micheletti, Gabriele ;

Calonghi, Natalia ;

Farruggia, Giovanna ;

Strocchi, Elena ;

Palmacci, Vincenzo ;

Telese, Dario ;

Bordoni, Silvia ;

Frisco, Giulia ;

Boga, Carla .

MOLECULES, 2020, 25 (02)

[8] Friedel-Crafts-Type Acylation and Amidation Reactions in Strong Bronsted Acid: Taming Superelectrophiles [J].

Sumita, Akinari ;

Ohwada, Tomohiko .

MOLECULES, 2022, 27 (18)

[9] Indole Derivative Interacts with Estrogen Receptor Beta and Inhibits Human Ovarian Cancer Cell Growth [J].

Verardi, Laura ;

Fiori, Jessica ;

Andrisano, Vincenza ;

Locatelli, Alessandra ;

Morigi, Rita ;

Naldi, Marina ;

Bertucci, Carlo ;

Strocchi, Elena ;

Boga, Carla ;

Micheletti, Gabriele ;

Calonghi, Natalia .

MOLECULES, 2020, 25 (19)

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