Moving the Needle on Alzheimer's Disease with an Anti-Oligomer Antibody

被引：13

作者：

Gandy, Sam ^{[1
,2
,5
,6
]}

Ehrlich, Michelle E. ^{[1
,3
,4
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Pediat, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

[5] Icahn Sch Med Mt Sinai, Alzheimers Dis Res Ctr, New York, NY 10029 USA

[6] James J Peters Dept Vet Affairs Med Ctr, Bronx, NY 10468 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2023年 / 388卷 / 01期

关键词：

MUTATION; DUTCH;

D O I：

10.1056/NEJMe2214981

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：80 / 81

页数：2

共 14 条

[1] Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease [J].

Castranio, Emilie L. ;

Hasel, Philip ;

Haure-Mirande, Jean-Vianney ;

Ramirez Jimenez, Angie V. ;

Hamilton, B. Wade ;

Kim, Rachel D. ;

Glabe, Charles G. ;

Wang, Minghui ;

Zhang, Bin ;

Gandy, Sam ;

Liddelow, Shane A. ;

Ehrlich, Michelle E. .

ALZHEIMERS & DEMENTIA, 2022, :2239-2252

[2]

Chen X., 2022, IMMUNITY

[3]

Ehrlich ME., 2022, 8 INT CEREBRAL AMYLO

[4] Protofibril assemblies of the arctic, dutch, and flemish mutants of the Alzheimer's Aβ1-40 peptide [J].

Fawzi, Nicolas Lux ;

Kohlstedt, Kevin L. ;

Okabe, Yuka ;

Head-Gordon, Teresa .

BIOPHYSICAL JOURNAL, 2008, 94 (06) :2007-2016

[5] Days to Criterion as an Indicator of Toxicity Associated with Human Alzheimer Amyloid-β Oligomers [J].

Gandy, Sam ;

Simon, Adam J. ;

Steele, John W. ;

Lublin, Alex L. ;

Lah, James J. ;

Walker, Lary C. ;

Levey, Allan I. ;

Krafft, Grant A. ;

Levy, Efrat ;

Checler, Frederic ;

Glabe, Charles ;

Bilker, Warren B. ;

Abel, Ted ;

Schmeidler, James ;

Ehrlich, Michelle E. .

ANNALS OF NEUROLOGY, 2010, 68 (02) :220-230

[6] Harnessing Immunoproteostasis to Treat Neurodegenerative Disorders [J].

Golde, Todd E. .

NEURON, 2019, 101 (06) :1003-1015

[7] Soluble Arctic amyloid β protein inhibits hippocampal long-term potentiation in vivo [J].

Klyubin, I ;

Walsh, DM ;

Cullen, WK ;

Fadeeva, JV ;

Anwyl, R ;

Selkoe, DJ ;

Rowan, MJ .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 19 (10) :2839-2846

[8] MUTATION OF THE ALZHEIMERS-DISEASE AMYLOID GENE IN HEREDITARY CEREBRAL-HEMORRHAGE, DUTCH TYPE [J].

LEVY, E ;

CARMAN, MD ;

FERNANDEZMADRID, IJ ;

POWER, MD ;

LIEBERBURG, I ;

VANDUINEN, SG ;

BOTS, GTAM ;

LUYENDIJK, W ;

FRANGIONE, B .

SCIENCE, 1990, 248 (4959) :1124-1126

[9] The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation [J].

Nilsberth, C ;

Westlind-Danielsson, A ;

Eckman, CB ;

Condron, MM ;

Axelman, K ;

Forsell, C ;

Stenh, C ;

Luthman, J ;

Teplow, DB ;

Younkin, SG ;

Näslund, J ;

Lannfelt, L .

NATURE NEUROSCIENCE, 2001, 4 (09) :887-893

[10] Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline [J].

Ossenkoppele, Rik ;

Binette, Alexa Pichet ;

Groot, Colin ;

Smith, Ruben ;

Strandberg, Olof ;

Palmqvist, Sebastian ;

Stomrud, Erik ;

Tideman, Pontus ;

Ohlsson, Tomas ;

Jogi, Jonas ;

Johnson, Keith ;

Sperling, Reisa ;

Dore, Vincent ;

Masters, Colin L. ;

Rowe, Christopher ;

Visser, Denise ;

van Berckel, Bart N. M. ;

van der Flier, Wiesje M. ;

Baker, Suzanne ;

Jagust, William J. ;

Wiste, Heather J. ;

Petersen, Ronald C. ;

Jack, Clifford R., Jr. ;

Hansson, Oskar .

NATURE MEDICINE, 2022, 28 (11) :2381-+

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