Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease

被引:4
作者
Ayyildiz, Sevilay [1 ,2 ]
Velioglu, Halil Aziz [3 ,4 ]
Ayyildiz, Behcet [1 ,2 ]
Sutcubasi, Bernis [5 ]
Hanoglu, Lutfu [4 ,6 ]
Bayraktaroglu, Zubeyir [4 ,7 ]
Yildirim, Suleyman [8 ]
Atasever, Alper [9 ]
Yulug, Burak [10 ]
机构
[1] Kocaeli Univ, Grad Sch Hlth Sci, Anat PhD Program, Kocaeli, Turkey
[2] Istinye Univ, Sch Med, Dept Anat, Istanbul, Turkey
[3] Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden
[4] Istanbul Medipol Univ, Regenerat & Restorat Med Res Ctr REMER, Hlth Sci & Technol Res Inst SABITA, Funct Imaging & Cognit Affect Neurosci Lab fINCAN, Istanbul, Turkey
[5] Acibadem Univ, Fac Arts & Sci, Dept Psychol, Istanbul, Turkey
[6] Istanbul Medipol Univ, Sch Med, Dept Neurol, Istanbul, Turkey
[7] Istanbul Medipol Univ, Int Sch Med, Dept Physiol, Istanbul, Turkey
[8] Istanbul Medipol Univ, Int Sch Med, Dept Med Microbiol, Istanbul, Turkey
[9] Istanbul Medipol Univ, Int Sch Med, Dept Anat, Istanbul, Turkey
[10] Alanya Alaaddin Keykubat Univ, Sch Med, Dept Neurol, Antalya, Turkey
关键词
Alzheimer's disease; claustrum; elderly people; functional connectivity; Parkinson's disease;
D O I
10.1002/hbm.26171
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical areas as well as subcortical structures. Although the claustrum has been involved in several neurodegenerative diseases, specific changes in connections of the claustrum remain unclear in Alzheimer's disease (AD), and Parkinson's disease (PD). Resting-state fMRI and T1-weighted structural 3D images from healthy elderly (n = 15), AD (n = 16), and PD (n = 12) subjects were analyzed. Seed-based FC analysis was performed using CONN FC toolbox and T1-weighted images were analyzed with the Computational Anatomy Toolbox for voxel-based morphometry analysis. While we observed a decreased FC between the left claustrum and sensorimotor cortex, auditory association cortex, and cortical regions associated with social cognition in PD compared with the healthy control group (HC), no significant difference was found in alterations in the FC of both claustrum comparing the HC and AD groups. In the AD group, high FC of claustrum with regions of sensorimotor cortex and cortical regions related to cognitive control, including cingulate gyrus, supramarginal gyrus, and insular cortex were demonstrated. In addition, the structural results show significantly decreased volume in bilateral claustrum in AD and PD compared with HC. There were no significant differences in the claustrum volumes between PD and AD groups so the FC may offer more precise findings in distinguishing changes for claustrum in AD and PD.
引用
收藏
页码:1741 / 1750
页数:10
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