Sarcopenia in patients with pancreatic cancer, an independant prognostic factor

被引：2

作者：

Mandl, Johanna ^{[1
]}

Baumer, Sebastian ^{[1
,3
]}

Holtzem, Bernadette ^{[1
]}

Theurer, Rainer ^{[2
]}

Zorger, Niels ^{[2
]}

Pech, Oliver ^{[1
]}

机构：

[1] Krankenhaus Barmherzige Bruder Regensburg, Klin Gastroenterol & Interventionelle Endoskopie, Regensburg, Germany

[2] Krankenhaus Barmherzige Bruder Regensburg, Inst Radiol Neuroradiol & Nuklearmedizin, Regensburg, Germany

[3] Krankenhaus Barmherzige Bruder Regensburg, Klin Gastroenterol & Interventionelle Endoskopie, Prufeningerstr 86, D-93049 Regensburg, Germany

来源：

ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2023年 / 61卷 / 10期

关键词：

sarcopenia; pancreatic cancer; cancer cachexia; SKELETAL-MUSCLE; CACHEXIA; OBESITY; GEMCITABINE; SURVIVAL; CA-19-9; IMPACT; COMMON; INDEX;

D O I：

10.1055/a-1959-2894

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Pancreatic cancer is despite modern diagnostic tools and treatment regimen associated with poor outcome. Many patients show cachexia and sarcopenia.Methods In a retrospective analysis the SMI (cm(2)/m(2)) was measured by determining the skelettal muscle area in a computed tomography image at lumbar vertebrae 3. Further clinical parameters were measured to determine the outcome.Results The mean survival after diagnosis in the population with sarcopenia was significantly lower (14,4 vs 17,7 months, p=0,046). Significantly shorter survival was also seen for higher age (p=0,006), no tumor resection (p=0,004), metastases (p=0,002) and high CA19-9 level (p=0,002)Conclusion Sarcopenia is an indipendant prognostic factor in patients with pancreatic cancer. SMI should be measured clinical practice and further studies are necessary to asses a potential therapeutic strategy.

引用

页码：1365 / 1370

页数：6

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