Challenges in non-radiographic axial spondyloarthritis

被引:8
作者
Poddubnyy, Denis [1 ,2 ,3 ,4 ]
机构
[1] Charite Univ Med Berlin, Dept Gastroenterol Infectiol & Rheumatol, Hindenburgdamm 30, D-12203 Berlin, Germany
[2] Free Univ Berlin, Berlin, Germany
[3] Humboldt Univ, Berlin, Germany
[4] German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany
关键词
Axial spondyloarthritis; Non-radiographic axial spondyloarthritis; Ankylosing spondylitis; Diagnosis; Treatment; Imaging; MRI; ANKYLOSING-SPONDYLITIS; SACROILIITIS PROGRESSION; DIAGNOSIS; CRITERIA; DELAY; ONSET; RATES;
D O I
10.1016/j.jbspin.2022.105468
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Non-radiographic axial spondyloarthritis (nr-axSpA) is part of the spectrum or continuum of axSpA and is characterized by the absence of definite structural damage in the sacroiliac joints. The introduction of the concept of axSpA with two - non-radiographic and radiographic - stages stimulated activities related to the improvement of early diagnosis and treatment of this disease, but also opened a number of controversial topics in the field. In this article, we are discussing several challenges related to the concept of nr-axSpA, the diagnosis, and the treatment in the historical context and in the light of the recent data.(c) 2022 L'Auteur(s). Publie par Elsevier Masson SAS au nom de Societe franc , aise de rhumatologie. Cet article est publie en Open Access sous licence CC BY (http://creativecommons.org/licenses/by/4.0/).
引用
收藏
页数:5
相关论文
共 38 条
[1]   Frequency of MRI changes suggestive of axial spondyloarthritis in the axial skeleton in a large population-based cohort of individuals aged <45 years [J].
Baraliakos, Xenofon ;
Richter, Adrian ;
Feldmann, Daniel ;
Ott, Anne ;
Buelow, Robin ;
Schmidt, Carsten O. ;
Braun, Juergen .
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (02) :186-192
[2]   Do patients with axial spondyloarthritis with radiographic sacroiliitis fulfil both the modified New York criteria and the ASAS axial spondyloarthritis criteria? Results from eight cohorts [J].
Boel, Anne ;
Molto, Anna ;
van der Heijde, Desiree ;
Ciurea, Adrian ;
Dougados, Maxime ;
Gensler, Lianne S. ;
Santos, Maria-Jose ;
De Miguel, Eugenio ;
Poddubnyy, Denis ;
Rudwaleit, Martin ;
van Tubergen, Astrid ;
van Gaalen, Floris A. ;
Ramiro, Sofia .
ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 (11) :1545-1549
[3]   Magnetic Resonance Imaging of the Sacroiliac Joints Indicating Sacroiliitis According to the Assessment of SpondyloArthritis international Society Definition in Healthy Individuals, Runners, and Women With Postpartum Back Pain [J].
de Winter, Janneke ;
de Hooge, Manouk ;
van de Sande, Marleen ;
de Jong, Henriette ;
van Hoeven, Lonneke ;
de Koning, Anoek ;
Berg, Inger Jorid ;
Ramonda, Roberta ;
Baeten, Dominique ;
van der Heijde, Desiree ;
Weel, Angelique ;
Landewe, Robert .
ARTHRITIS & RHEUMATOLOGY, 2018, 70 (07) :1042-1048
[4]   Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial [J].
Deodhar, Atul ;
Van den Bosch, Filip ;
Poddubnyy, Denis ;
Maksymowych, Walter P. ;
van der Heijde, Desiree ;
Kim, Tae-Hwan ;
Kishimoto, Mitsumasa ;
Blanco, Ricardo ;
Duan, Yuanyuan ;
Li, Yihan ;
Pangan, Aileen L. ;
Wung, Peter ;
Song, In-Ho .
LANCET, 2022, 400 (10349) :369-379
[5]   Improvement of Signs and Symptoms of Nonradiographic Axial Spondyloarthritis in Patients Treated With Secukinumab: Primary Results of a Randomized, Placebo-Controlled Phase III Study [J].
Deodhar, Atul ;
Blanco, Ricardo ;
Dokoupilova, Eva ;
Hall, Stephen ;
Kameda, Hideto ;
Kivitz, Alan J. ;
Poddubnyy, Denis ;
van de Sande, Marleen ;
Wiksten, Anna S. ;
Porter, Brian O. ;
Richards, Hanno B. ;
Haemmerle, Sibylle ;
Braun, Juergen .
ARTHRITIS & RHEUMATOLOGY, 2021, 73 (01) :110-120
[6]   Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial [J].
Deodhar, Atul ;
van der Heijde, Desiree ;
Gensler, Lianne S. ;
Kim, Tae-Hwan ;
Maksymowych, Walter P. ;
Ostergaard, Mikkel ;
Poddubnyy, Denis ;
Marzo-Ortega, Helena ;
Bessette, Louis ;
Tomita, Tetsuya ;
Leung, Ann ;
Hojnik, Maja ;
Gallo, Gaia ;
Li, Xiaoqi ;
Adams, David ;
Carlier, Hilde ;
Sieper, Joachim .
LANCET, 2020, 395 (10217) :53-64
[7]   A Fifty-Two-Week, Randomized, Placebo-Controlled Trial of Certolizumab Pegol in Nonradiographic Axial Spondyloarthritis [J].
Deodhar, Atul ;
Gensler, Lianne S. ;
Kay, Jonathan ;
Maksymowych, Walter P. ;
Haroon, Nigil ;
Landewe, Robert ;
Rudwaleit, Martin ;
Hall, Stephen ;
Bauer, Lars ;
Hoepken, Bengt ;
de Peyrecave, Natasha ;
Kilgallen, Brian ;
van der Heijde, Desiree .
ARTHRITIS & RHEUMATOLOGY, 2019, 71 (07) :1101-1111
[8]   Choose wisely: imaging for diagnosis of axial spondyloarthritis [J].
Diekhoff, Torsten ;
Eshed, Iris ;
Radny, Felix ;
Ziegeler, Katharina ;
Proft, Fabian ;
Greese, Juliane ;
Deppe, Dominik ;
Biesen, Robert ;
Hermann, Kay Geert ;
Poddubnyy, Denis .
ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (02) :237-242
[9]   Sacroiliac radiographic progression in recent onset axial spondyloarthritis: the 5-year data of the DESIR cohort [J].
Dougados, Maxime ;
Sepriano, Alexandre ;
Molto, Anna ;
van Lunteren, Miranda ;
Ramiro, Sofia ;
de Hooge, Manouk ;
van den Berg, Rosaline ;
Compan, Victoria Navarro ;
Demattei, Christophe ;
Landewe, Robert ;
van der Heijde, Desiree .
ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (11) :1823-1828
[10]   The yield of a positive MRI of the spine as imaging criterion in the ASAS classification criteria for axial spondyloarthritis: results from the SPACE and DESIR cohorts [J].
Ez-Zaitouni, Zineb ;
Bakker, Pauline A. C. ;
van Lunteren, Miranda ;
de Hooge, Manouk ;
van den Berg, Rosaline ;
Reijnierse, Monique ;
Fagerli, Karen Minde ;
Landewe, Robert B. M. ;
Ramonda, Roberta ;
Jacobsson, Lennart T. H. ;
Saraux, Alain ;
Lenczner, Gregory ;
Feydy, Antoine ;
Pialat, Jean Baptiste ;
Thevenin, Fabrice ;
van Gaalen, Floris A. ;
van der Heijde, Desiree .
ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (10) :1731-1736