Mesenchymal Stem Cell-Derived Extracellular Vesicles: The Novel Therapeutic Option for Regenerative Dentistry

被引：3

作者：

Kong, Haiying ^{[1
,2
]}

Liu, Peiqi ^{[1
,2
,3
]}

Li, Hongwen ^{[1
,2
,4
]}

Zeng, Xiantao ^{[1
,2
]}

Xu, Peiwu ^{[1
,2
]}

Yao, Xinhui ^{[1
,2
]}

Liu, Senqing ^{[1
,2
]}

Cheng, Chak Kwong ^{[5
]}

Xu, Jian ^{[1
,2
,4
]}

机构：

[1] Longgang ENT Hosp, Dept Dent, Shenzhen, Guangdong, Peoples R China

[2] Inst ENT, Shenzhen Key Lab ENT, Shenzhen, Guangdong, Peoples R China

[3] Guangdong Med Univ, Sch Clin Med 2, Dongguan, Guangdong, Peoples R China

[4] Shenzhen Longgang Inst Stomatol, Shenzhen, Guangdong, Peoples R China

[5] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China

来源：

STEM CELL REVIEWS AND REPORTS | 2023年 / 19卷 / 01期

关键词：

Dental mesenchymal stem cells; Osteogenic differentiation; Regenerative dentistry; Extracellular vesicles; miRNAs; HUMAN DENTAL-PULP; EXFOLIATED DECIDUOUS TEETH; OSTEOGENIC DIFFERENTIATION; OSTEOBLASTIC DIFFERENTIATION; BONE REGENERATION; APICAL PAPILLA; TNF-ALPHA; EXOSOMES; PROLIFERATION; FOLLICLE;

D O I：

10.1007/s12015-022-10342-y

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Dental mesenchymal stem cells (MSCs) are characterized by unlimited self-renewal ability and high multidirectional differentiation potential. Since dental MSCs can be easily isolated and exhibit a high capability to differentiate into odontogenic cells, they are considered as attractive therapeutic agents in regenerative dentistry. Recently, MSC-derived extracellular vesicles (MSC-EVs) have attracted widespread attention as carriers for cell-free therapy due to their potential functions. Many studies have shown that MSC-EVs can mediate microenvironment at tissue damage site, and coordinate the regeneration process. Additionally, MSC-EVs can mediate intercellular communication, thus affecting the phenotypes and functions of recipient cells. In this review, we mainly summarized the types of MSCs that could be potentially applied in regenerative dentistry, the possible molecular cargos of MSC-EVs, and the major effects of MSC-EVs on the therapeutic induction of osteogenic differentiation.

引用

页码：46 / 58

页数：13

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