The therapeutic effects of marine sulfated polysaccharides on diabetic nephropathy

被引：6

作者：

Wu, Lijuan ^{[1
,2
,3
]}

Zhang, Xiaonan ^{[2
,3
]}

Zhao, Jun ^{[2
,3
]}

Yang, Menglin ^{[2
,3
]}

Yang, Jinbo ^{[1
,2
,3
]}

Qiu, Peiju ^{[1
,2
,3
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Yushan Rd, Qingdao 266003, Peoples R China

[2] Pilot Natl Lab Marine Sci & Technol Qingdao, Ctr Innovat Marine Drug Screening &Evaluat, Qingdao 266237, Peoples R China

[3] Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 261卷

关键词：

Marine sulfated polysaccharide; Diabetic nephropathy; Mechanisms; Structure-activity relationship; MOLECULAR-WEIGHT FUCOIDAN; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLAST-GROWTH-FACTOR; P-SELECTIN; STRUCTURAL-CHARACTERIZATION; ENDOTHELIAL GLYCOCALYX; HEPARANASE; BINDING; SULODEXIDE; DISEASE;

D O I：

10.1016/j.ijbiomac.2024.129269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Marine sulfated polysaccharide (MSP) is a natural high molecular polysaccharide containing sulfate groups, which widely exists in various marine organisms. The sources determine structural variabilities of MSPs which have high security and wide biological activities, such as anticoagulation, antitumor, antivirus, immune regulation, regulation of glucose and lipid metabolism, antioxidant, etc. Due to the structural similarities between MSP and endogenous heparan sulfate, a majority of studies have shown that MSP can be used to treat diabetic nephropathy (DN) in vivo and in vitro. In this paper, we reviewed the anti-DN activities, the dominant mechanisms and structure-activity relationship of MSPs in order to provide the overall scene of MSPs as a modality of treating DN.

引用

页数：12

共 97 条

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