Lanostane triterpenoids from artificially cultivated fruiting bodies of Ganoderma wiiroense

被引：1

作者：

Yangchum, Arunrat ^{[1
]}

Srichomthong, Kitlada ^{[1
]}

Thummarukcharoen, Tuksaporn ^{[2
]}

Sommai, Sujinda ^{[1
]}

Isaka, Masahiko ^{[1
]}

机构：

[1] Natl Sci & Technol Dev Agcy NSTDA, Natl Ctr Genet Engn & Biotechnol BIOTEC, 111 Thailand Sci Pk,Phahonyothin Rd, Klongluang 12120, Pathumthani, Thailand

[2] Natl Sci & Technol Dev Agcy NSTDA, Natl Biobank Thailand, 111 Thailand Sci Pk,Phahonyothin Rd, Klongluang 12120, Pathumthani, Thailand

来源：

PHYTOCHEMISTRY LETTERS | 2023年 / 58卷

关键词：

Ganoderma wiiroense; Polyporaceae; Lanostane; Antitubercular activity;

D O I：

10.1016/j.phytol.2023.10.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven undescribed lanostane triterpenoids (1-7) were isolated from artificially cultivated fruiting bodies of Ganoderma wiiroense, strain TBRC-BCC 60613. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The C-23 absolute configuration of 1 was determined to be 23 S using the modified Mosher's method. The isolated compounds were evaluated for their antitubercular and antimalarial activities. Compound 7 showed activity against Mycobacterium tuberculosis H37Ra (MIC 50 mu g/ml).

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页码：69 / 75

页数：7

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