Allergen immunotherapy for allergic asthma: The future seems bright

被引：18

作者：

Diamant, Zuzana ^{[1
,2
,3
,4
,5
]}

van Maaren, Maurits ^{[6
]}

Muraro, Antonella ^{[7
]}

Jesenak, Milos ^{[8
,9
,10
]}

Striz, Ilja ^{[11
]}

机构：

[1] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, KU Leuven, Leuven, Belgium

[2] Lund Univ, Skane Univ Hosp, Inst Clin Sci, Dept Resp Med & Allergol, Lund, Sweden

[3] Charles Univ Prague, Fac Med 1, Dept Resp Med, Prague, Czech Republic

[4] Thomayer Hosp, Prague, Czech Republic

[5] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands

[6] Erasmus MC Univ Med Ctr, Dept Internal Med Allergy & Clin Immunol, Rotterdam, Netherlands

[7] Padua Univ Hosp, Food Allergy Referral Ctr, Padua, Italy

[8] Comenius Univ, Univ Teaching Hosp Martin, Jessenius Fac Med, Dept Pediat, Martin, Slovakia

[9] Comenius Univ, Univ Teaching Hosp Martin, Jessenius Fac Med, Dept Pulmonol & Phthisiol, Martin, Slovakia

[10] Comenius Univ, Univ Teaching Hosp Martin, Jessenius Fac Med, Dept Allergol & Clin Immunol, Martin, Slovakia

[11] Inst Clin & Expt Med, Dept Clin & Transplant Immunol, Prague, Czech Republic

来源：

RESPIRATORY MEDICINE | 2023年 / 210卷

关键词：

Allergen immunotherapy; Mechanisms; Clinical effectiveness; Prevention; Disease remission; Asthma; Disease modification; SUBLINGUAL IMMUNOTHERAPY; EAACI GUIDELINES; MECHANISMS; RHINITIS; ADHERENCE; EFFICACY; CELLS;

D O I：

10.1016/j.rmed.2023.107125

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term effectiveness of house dust mite (HDM) AIT in a large group of patients with HDM-driven asthma further underscored its unique therapeutic potential as well as confirmed previous data with pollen AIT. More widespread use of this causal treatment in select patient populations should further move this promising therapeutic field. In this mini-review, we discuss updates on new insights based on real world patient data.

引用

页数：6

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