Propagative isatin in organic synthesis of spirooxindoles through catalysis

Oxindole (indoline-2, 3-dione) has been utilized to a great extent in heterocyclic scaffold syntheses as a futuristic medication and is considered a prominent building block used in organic synthesis. Herein, oxindole promotes multi-component reactions w.r.t. initiative candidates for the formation of spiroox-indole scaffolds. This review reflects the advances of oxindole in organic synthesis as a selected starting material in the formation of spirooxindoles from 2015 to 2022. Remarkable spirooxindoles have isolated distinct genus (plants and animals), and their origins have significant recreation opportunities in me-dicinal chemistry. Spiro-skeleton compounds have cyclic structures which are fused on a central carbon (sp3 hybridized), obtaining interesting conformational features to favour anti-proliferation evaluation. The obvious reaction mechanisms involve the plausible reactivity of the reactants, the catalyst interac-tion, and the cyclization to produce spirooxindole derivatives. (c) 2023 Elsevier Ltd. All rights reserved.