Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Cancer Antigen 125, Prostate-Specific Antigen and Other Cancer Markers: A Primer on Commonly Used Cancer Markers

被引：26
作者：
Desai, Shreya [1 ]
Guddati, Achuta K. [1 ]
机构：
[1] Augusta Univ, Georgia Canc Ctr, Div Hematol Oncol, Augusta, GA 30912 USA
来源：
WORLD JOURNAL OF ONCOLOGY | 2023年 / 14卷 / 01期
关键词：
Tumor markers; Serum markers; CA; 19-9; CEA; AFP; Cancer screening; Prognostic markers; CA-125; PSA; 27-29; B-hCG; Calcitonin; 5-HIAA; LDH; THYROID ASSOCIATION GUIDELINES; OVARIAN-CANCER; TUMOR-MARKERS; PANCREATIC-CANCER; AMERICAN SOCIETY; AFRICAN-AMERICAN; PROGNOSTIC INDEX; TASK-FORCE; SERUM; CA-19-9;
D O I：
10.14740/wjon1425
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer markers are molecules produced by cancer cells which may serve to identify the presence of cancer. Cancer markers can be dif-ferentiated as serum-based, radiology-based and tissue-based, and are one of the most important tools in diagnosing, staging and moni-toring of treatment of many cancers. The most used cancer markers are serum cancer markers due to its relative ease and lower cost of testing. However, serum cancer markers have poor mass screening utilization due to poor positive predictive value. Several markers such as prostate-specific antigen (PSA), beta-human chorionic gon-adotropin (B-hCG), alpha-fetoprotein (AFP), and lactate dehydro-genase (LDH) are used to aid in diagnosis of cancer in cases of high suspicion. Serum markers such as carcinoembryonic antigen (CEA), AFP, carbohydrate antigen 19-9 (CA 19-9), and 5-hydrox-yindoleacetic acid (5-HIAA) play a significant role in assessing dis-ease prognosis as well as response to treatment. This work reviews the role of some of the biomarkers in the diagnosis and treatment of cancer.
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页码：4 / 14
页数：11
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