Management of transfusion-dependent β-thalassemia (TDT): Expert insights and practical overview from the Middle East

被引：8
作者：
El-Beshlawy, Amal [1 ]
Dewedar, Hany [2 ]
Hindawi, Salwa [3 ]
Alkindi, Salam [4 ]
Tantawy, Azza A. [5 ]
Yassin, Mohamed A. [6 ]
Taher, Ali T. [7 ,8 ]
机构：
[1] Cairo Univ, Fac Med, Dept Pediat Hematol, Cairo, Egypt
[2] Latifa Hosp, Thalassemia Ctr, Dubai, U Arab Emirates
[3] King Abdulaziz Univ, Fac Med, Dept Hematol, Jeddah, Saudi Arabia
[4] Sultan Qaboos Univ Hosp, Dept Hematol, Muscat, Oman
[5] Ain Shams Univ, Fac Med, Dept Pediat, Cairo, Egypt
[6] Hamad Med Corp, Natl Ctr Canc Care & Res, Dept Hematol & Oncol, Doha, Qatar
[7] Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon
[8] Amer Univ Beirut, Naef K Basile Canc Inst, Med Ctr, Hematol & Oncol,Dept Internal Med,Res, POB 11-0236, Beirut 11072020, Lebanon
来源：
BLOOD REVIEWS | 2024年 / 63卷
关键词：
Thalassemia; Complications; Transfusion; iron chelation; Management; STEM-CELL TRANSPLANTATION; GENETIC-COUNSELING PROGRAM; MAJOR PATIENTS RELATION; PEDIATRIC-PATIENTS; IRON CHELATION; PULMONARY-HYPERTENSION; FOLLOW-UP; DEFERASIROX; COMPLICATIONS; PREVALENCE;
D O I：
10.1016/j.blre.2023.101138
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
beta-Thalassemia is one of the most common monogenetic diseases worldwide, with a particularly high prevalence in the Middle East region. As such, we have developed long-standing experience with disease management and devising solutions to address challenges attributed to resource limitations. The region has also participated in the majority of clinical trials and development programs of iron chelators and more novel ineffective erythropoiesistargeted therapy. In this review, we provide a practical overview of management for patients with transfusiondependent beta-thalassemia, primarily driven by such experiences, with the aim of transferring knowledge to colleagues in other regions facing similar challenges.
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页数：10
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