Advanced flow cytometry for biomedical applications

被引：7

作者：

Pang, Kai ^{[1
]}

Dong, Sihan ^{[2
]}

Zhu, Yuxi ^{[1
]}

Zhu, Xi ^{[3
,4
]}

Zhou, Quanyu ^{[3
,4
]}

Gu, Bobo ^{[3
,4
]}

Jin, Wei ^{[5
]}

Zhang, Rui ^{[2
]}

Fu, Yuting ^{[2
]}

Yu, Bingchen ^{[1
]}

Sun, Da ^{[1
]}

Zheng, Duanmu ^{[1
]}

Wei, Xunbin ^{[5
]}

机构：

[1] Beijing Informat Sci & Technol Univ, Sch Instrument Sci & Optoelect Engn, Beijing, Peoples R China

[2] Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing, Peoples R China

[3] Shanghai Jiao Tong Univ, Medx Res Inst, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China

[5] Peking Univ, Int Canc Inst, Beijing 100191, Peoples R China

来源：

JOURNAL OF BIOPHOTONICS | 2023年 / 16卷 / 09期

基金：

美国国家科学基金会;

关键词：

flow cytometry; imaging flow cytometry; in vivo flow cytometry; microfluidic flow cytometry; photoacoustic flow cytometry; Raman flow cytometry; CIRCULATING TUMOR-CELLS; RAMAN SCATTERING MCARS; ACUTE MYELOID-LEUKEMIA; BONE-MARROW; HIGH-THROUGHPUT; CANCER-CELLS; BLOOD; APOPTOSIS; BACTERIA; EXPRESSION;

D O I：

10.1002/jbio.202300135

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Flow cytometry (FC) is a versatile tool with excellent capabilities to detect and measure multiple characteristics of a population of cells or particles. Notable advancements in in vivo photoacoustic FC, coherent Raman FC, microfluidic FC, and so on, have been achieved in the last two decades, which endows FC with new functions and expands its applications in basic research and clinical practice. Advanced FC broadens the tools available to researchers to conduct research involving cancer detection, microbiology (COVID-19, HIV, bacteria, etc.), and nucleic acid analysis. This review presents an overall picture of advanced flow cytometers and provides not only a clear understanding of their mechanisms but also new insights into their practical applications. We identify the latest trends in this area and aim to raise awareness of advanced techniques of FC. We hope this review expands the applications of FC and accelerates its clinical translation.

引用

页数：16

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