CD4+ T cells are critical components of the adaptive immune system. The T cell receptor (TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T cells. TCR signaling plays a crucial role in T cell development, antigen recognition, activation, and differentiation upon recognition of foreign-or auto-antigens. In specific autoimmune conditions, altered TCR repertoire is reported and can predispose autoimmunity with organ-specific inflammation and tissue damage. TCR signaling modulates various signaling cascades and regu-lates epigenetic and transcriptional regulation during homeostasis and disease conditions. Understanding the mechanism by which coreceptors and cytokine signals control the magnitude of TCR signal amplification will aid in developing therapeutic strategies to treat inflammation and autoimmune diseases. This review focuses on the role of the TCR signaling cascade and its components in the activation, differentiation, and plasticity of various CD4+ T cell subsets.
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Araya, Natsumi
Sato, Tomoo
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St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Sato, Tomoo
Ando, Hitoshi
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St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Ando, Hitoshi
Tomaru, Utano
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机构:
Hokkaido Univ, Grad Sch Med, Dept Pathol, Sapporo, Hokkaido 060, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Tomaru, Utano
Yoshida, Mari
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h-index: 0
机构:
Aichi Med Univ, Inst Med Sci Aging, Nagakute, Aichi, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Yoshida, Mari
Coler-Reilly, Ariella
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St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Coler-Reilly, Ariella
Yagishita, Naoko
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机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Yagishita, Naoko
Yamauchi, Junji
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St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Yamauchi, Junji
Hasegawa, Atsuhiko
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h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Immunotherapeut, Tokyo, Japan
St Marianna Univ, Sch Med, Dept Neurol, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Hasegawa, Atsuhiko
Kannagi, Mari
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h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Immunotherapeut, Tokyo, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Kannagi, Mari
Hasegawa, Yasuhiro
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机构:St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Hasegawa, Yasuhiro
Takahashi, Katsunori
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St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Takahashi, Katsunori
Kunitomo, Yasuo
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St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Kunitomo, Yasuo
Tanaka, Yuetsu
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机构:
Univ Ryukyus, Grad Sch Med, Dept Immunol, Nishihara, Okinawa 90301, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Tanaka, Yuetsu
Nakajima, Toshihiro
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Tokyo Med Univ, Inst Med Sci, Tokyo 1608402, Japan
Tokyo Med Univ, Clin Res Ctr, Tokyo 1608402, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Nakajima, Toshihiro
Nishioka, Kusuki
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Tokyo Med Univ, Inst Med Sci, Tokyo 1608402, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Nishioka, Kusuki
Utsunomiya, Atae
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机构:
Imamura Bun In Hosp, Dept Hematol, Kagoshima, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
机构:
Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Bailey-Bucktrout, Samantha L.
Martinez-Llordella, Marc
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h-index: 0
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Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Martinez-Llordella, Marc
Zhou, Xuyu
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机构:
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100864, Peoples R ChinaUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Zhou, Xuyu
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Anthony, Bryan
Rosenthal, Wendy
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Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Rosenthal, Wendy
Luche, Herve
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h-index: 0
机构:
Univ Clin Ulm, Inst Immunol, D-8901 Ulm, GermanyUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Luche, Herve
Fehling, Hans J.
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h-index: 0
机构:
Univ Clin Ulm, Inst Immunol, D-8901 Ulm, GermanyUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Fehling, Hans J.
Bluestone, Jeffrey A.
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h-index: 0
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Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Bartleson, Juliet M.
Viehmann Milam, Ashley A.
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
St Louis Univ, Dept Biol, St Louis, MO 63103 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Viehmann Milam, Ashley A.
Donermeyer, David L.
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机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Donermeyer, David L.
Horvath, Stephen
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机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Horvath, Stephen
Xia, Yu
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Xia, Yu
Egawa, Takeshi
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Egawa, Takeshi
Allen, Paul M.
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Araya, Natsumi
Sato, Tomoo
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h-index: 0
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Sato, Tomoo
Ando, Hitoshi
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h-index: 0
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St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Ando, Hitoshi
Tomaru, Utano
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h-index: 0
机构:
Hokkaido Univ, Grad Sch Med, Dept Pathol, Sapporo, Hokkaido 060, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Tomaru, Utano
Yoshida, Mari
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h-index: 0
机构:
Aichi Med Univ, Inst Med Sci Aging, Nagakute, Aichi, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Yoshida, Mari
Coler-Reilly, Ariella
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h-index: 0
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Coler-Reilly, Ariella
Yagishita, Naoko
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h-index: 0
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Yagishita, Naoko
Yamauchi, Junji
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h-index: 0
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Yamauchi, Junji
Hasegawa, Atsuhiko
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Immunotherapeut, Tokyo, Japan
St Marianna Univ, Sch Med, Dept Neurol, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Hasegawa, Atsuhiko
Kannagi, Mari
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h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Immunotherapeut, Tokyo, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Kannagi, Mari
Hasegawa, Yasuhiro
论文数: 0引用数: 0
h-index: 0
机构:St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Hasegawa, Yasuhiro
Takahashi, Katsunori
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h-index: 0
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Takahashi, Katsunori
Kunitomo, Yasuo
论文数: 0引用数: 0
h-index: 0
机构:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Kunitomo, Yasuo
Tanaka, Yuetsu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ryukyus, Grad Sch Med, Dept Immunol, Nishihara, Okinawa 90301, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Tanaka, Yuetsu
Nakajima, Toshihiro
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med Univ, Inst Med Sci, Tokyo 1608402, Japan
Tokyo Med Univ, Clin Res Ctr, Tokyo 1608402, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Nakajima, Toshihiro
Nishioka, Kusuki
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h-index: 0
机构:
Tokyo Med Univ, Inst Med Sci, Tokyo 1608402, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
Nishioka, Kusuki
Utsunomiya, Atae
论文数: 0引用数: 0
h-index: 0
机构:
Imamura Bun In Hosp, Dept Hematol, Kagoshima, JapanSt Marianna Univ, Sch Med, Inst Med Sci, Dept Rare Dis Res, Kawasaki, Kanagawa 2168512, Japan
机构:
Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Bailey-Bucktrout, Samantha L.
Martinez-Llordella, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Martinez-Llordella, Marc
Zhou, Xuyu
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100864, Peoples R ChinaUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Zhou, Xuyu
论文数: 引用数:
h-index:
机构:
Anthony, Bryan
Rosenthal, Wendy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Rosenthal, Wendy
Luche, Herve
论文数: 0引用数: 0
h-index: 0
机构:
Univ Clin Ulm, Inst Immunol, D-8901 Ulm, GermanyUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Luche, Herve
Fehling, Hans J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Clin Ulm, Inst Immunol, D-8901 Ulm, GermanyUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Fehling, Hans J.
Bluestone, Jeffrey A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Bartleson, Juliet M.
Viehmann Milam, Ashley A.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
St Louis Univ, Dept Biol, St Louis, MO 63103 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Viehmann Milam, Ashley A.
Donermeyer, David L.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Donermeyer, David L.
Horvath, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Horvath, Stephen
Xia, Yu
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Xia, Yu
Egawa, Takeshi
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA
Egawa, Takeshi
Allen, Paul M.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA