The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

被引：21
|
作者：
Yu, Haiyun [1 ]
Guan, Fei [1 ]
Miller, Heather [2 ]
Lei, Jiahui [1 ]
Liu, Chaohong [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan, Peoples R China
[2] Natl Inst Allergy & Infect Dis, NIH, Lab Intracellular Parasites, Rocky Mt Labs, Hamilton, MT USA
来源：
EMERGING MICROBES & INFECTIONS | 2023年 / 12卷 / 01期
关键词：
SARS-CoV-2; nucleocapsid; inflammation; cell death; innate immunity; adapted immunity; vaccine; I INTERFERON; COVID-19; RESPONSES; EVASION;
D O I：
10.1080/22221751.2022.2164219
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adaptive immunity.
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页数：12
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