The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

被引：20

作者：

Yu, Haiyun ^{[1
]}

Guan, Fei ^{[1
]}

Miller, Heather ^{[2
]}

Lei, Jiahui ^{[1
]}

Liu, Chaohong ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan, Peoples R China

[2] Natl Inst Allergy & Infect Dis, NIH, Lab Intracellular Parasites, Rocky Mt Labs, Hamilton, MT USA

来源：

EMERGING MICROBES & INFECTIONS | 2023年 / 12卷 / 01期

关键词：

SARS-CoV-2; nucleocapsid; inflammation; cell death; innate immunity; adapted immunity; vaccine; I INTERFERON; COVID-19; RESPONSES; EVASION;

D O I：

10.1080/22221751.2022.2164219

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adaptive immunity.

引用

页数：12

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