Radiotherapy of Orbital and Ocular Adnexa Lymphoma: Literature Review and University of Catania Experience

被引：3

作者：

La Rocca, Madalina ^{[1
]}

Leonardi, Barbara Francesca ^{[1
]}

Lo Greco, Maria Chiara ^{[1
]}

Marano, Giorgia ^{[1
]}

Finocchiaro, Irene ^{[1
]}

Iudica, Arianna ^{[1
]}

Milazzotto, Roberto ^{[2
]}

Liardo, Rocco Luca Emanuele ^{[2
]}

La Monaca, Viviana Anna ^{[2
]}

Salamone, Vincenzo ^{[2
]}

Basile, Antonio ^{[3
,4
]}

Foti, Pietro Valerio ^{[3
,4
]}

Palmucci, Stefano ^{[3
,4
]}

David, Emanuele ^{[4
]}

Parisi, Silvana ^{[1
]}

Pontoriero, Antonio ^{[1
]}

Pergolizzi, Stefano ^{[1
]}

Spatola, Corrado ^{[2
,3
,4
]}

机构：

[1] Univ Messina, Dept Biomed Dent & Morphol & Funct Imaging Sci, Radiat Oncol Unit, I-98122 Messina, Italy

[2] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Radiat Oncol Unit, I-95123 Catania, Italy

[3] Univ Hosp Policlin G Rodolico San Marco, Dept Med Surg Sci & Adv Technol GF Ingrassia, I-95123 Catania, Italy

[4] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Radiol Unit 1, I-95123 Catania, Italy

来源：

CANCERS | 2023年 / 15卷 / 24期

关键词：

orbit; orbital tumors; lymphoma; ocular oncology; radiation oncology; radiotherapy; proton beam radiotherapy; MARGINAL ZONE LYMPHOMA; INVOLVED-FIELD RADIOTHERAPY; RADIATION-THERAPY EFFICACY; LONG-TERM OUTCOMES; B-CELL LYMPHOMA; MALT LYMPHOMA; CHLAMYDIA-PSITTACI; FOLLOW-UP; MANAGEMENT; CLASSIFICATION;

D O I：

10.3390/cancers15245782

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Lymphomas are rarely localized in the ocular and orbital regions. Although their diagnosis is often complicated due to the similarity with other pathologies of this anatomical district, they are characterized by a good prognosis in the vast majority of cases. This article reports our clinical experience in the field, associating it with a review of the main therapeutic options, placing greater attention on the role of radiotherapy in the treatment of these tumors.Abstract Orbital and ocular adnexa lymphomas are rare neoplasms confined to the orbital region. The prognosis is generally favorable, with a high proportion of localized disease, indolent clinical course, prolonged disease-free intervals, and low lymphoma-related mortality rate. We report our experience on eleven patients with confirmed histological diagnosis of lymphoma stage IE-IIE, treated between 2010 and 2021 with radiotherapy alone or in association with chemotherapy or immunotherapy. Eight patients were treated with primary radiotherapy only, while three received previous systemic treatments. Six patients were treated with Proton beam therapy (PBT), and five with external beam radiotherapy (EBRT). The five-year local control rate was 98%; only one patient developed an out-of-field recurrence. We also conducted a comprehensive literature review using electronic databases (PubMed, EMBASE, and Cochrane Library). Articles were selected based on their pertinence to treatment of the ocular and adnexal lymphoma focusing on radiotherapy techniques (electron beam radiotherapy, photon beam radiotherapy, or proton beam radiotherapy), treatment total dose, fractionation schedule, early and late radio-induced toxicities, and patient's clinical outcome. Radiotherapy is an effective treatment option for orbital lymphoma, especially as standard treatment in the early stage of orbital lymphoma, with excellent local control rate and low rates of toxicity.

引用

页数：15