The impact of Bacillus Calmette-Guerin vaccination on antibody response after COVID-19 vaccination

被引：2
作者：
Taks, Esther J. M. [1 ,2 ]
Moorlag, Simone J. C. F. M. [1 ,2 ]
Fohse, Konstantin [1 ,2 ]
Simonetti, Elles [2 ,3 ]
van der Gaast-de Jongh, Christa E. [2 ,3 ]
van Werkhoven, Cornelis H. [4 ]
Bonten, Marc J. M. [4 ]
ten Oever, Jaap [1 ,2 ]
de Jonge, Marien I. [2 ,3 ]
van de Wijgert, Janneke H. H. M. [4 ]
Netea, Mihai G. [1 ,2 ,5 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, Lab Med Immunol, Nijmegen, Netherlands
[4] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
[5] Univ Bonn, Dept Immunol & Metab, Life & Med Sci Inst LIMES, Bonn, Germany
来源：
ISCIENCE | 2023年 / 26卷 / 11期
基金：
欧洲研究理事会;
关键词：
BCG VACCINATION; PROTECTION; INFECTION; SEX; AGE;
D O I：
10.1016/j.isci.2023.108062
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Earlier studies showed that BCG vaccination improves antibody responses of subsequent vaccinations. Similarly, in older volunteers we found an increased IgG receptor-binding domain (RBD) concentration after SARS-CoV-2 infection if they were recently vaccinated with BCG. This study aims to assess the effect of BCG on the serum antibody concentrations induced by COVID-19 vaccination in a population of adults older than 60 years. Serum was collected from 1,555 participants of the BCG-CORONA-ELDERLY trial a year after BCG or placebo, and we analyzed the anti-SARS-CoV-2 antibody concentrations using a fluorescent-microsphere-based multiplex immunoassay. Individuals who received the full primary COVID-19 vaccination series before serum collection and did not test positive for SARS-CoV-2 between inclusion and serum collection were included in analyses (n = 945). We found that BCG vaccination before first COVID-19 vaccine (median 347 days [IQR 329-359]) did not significantly impact the IgG RBD concentration after COVID-19 vaccination in an older European population.
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页数：12
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