Effects of pyrrolopyrimidine derivatives on cancer cells cultured in vitro and potential mechanism

被引：0

作者：

Kilic-Kurt, Zuhal ^{[1
]}

Celik, Aybuke ^{[2
]}

Bakar-Ates, Filiz ^{[2
]}

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06560 Ankara, Turkiye

[2] Ankara Univ, Fac Pharm, Dept Biochem, TR-06560 Ankara, Turkiye

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2024年 / 397卷 / 05期

关键词：

Anticancer; Pyrrolopyrimidine derivatives; MMP-9 inhibitor activity; Oxidative stress; OXIDATIVE STRESS; INHIBITORS; APOPTOSIS; COMPLEX; DESIGN;

D O I：

10.1007/s00210-023-02799-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, the anticancer activities of some pyrrolopyrimidine derivatives were evaluated. Compound 3 is the most cytotoxic compound on MCF-7 cancer cells with an IC50 value of 23.42 mu M. Also, compound 3 induced apoptosis and the ROS(+) cell population in MCF-7 cells. Moreover, it significantly reduced MMP-9 activity, having 42.16 +/- 5.10% and 58.28 +/- 1.96% inhibitory activities at 10 mu M and 50 mu M concentrations, respectively. Molecular docking results supported the activity, showing key hydrogen bonds with the binding site of MMP-9. Therefore, compound 3 might be a lead compound for the development of potent MMP-9 inhibitors.

引用

页码：3169 / 3177

页数：9

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