Effects of pyrrolopyrimidine derivatives on cancer cells cultured in vitro and potential mechanism

被引：0
|
作者：
Kilic-Kurt, Zuhal [1 ]
Celik, Aybuke [2 ]
Bakar-Ates, Filiz [2 ]
机构：
[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06560 Ankara, Turkiye
[2] Ankara Univ, Fac Pharm, Dept Biochem, TR-06560 Ankara, Turkiye
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2024年 / 397卷 / 05期
关键词：
Anticancer; Pyrrolopyrimidine derivatives; MMP-9 inhibitor activity; Oxidative stress; OXIDATIVE STRESS; INHIBITORS; APOPTOSIS; COMPLEX; DESIGN;
D O I：
10.1007/s00210-023-02799-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, the anticancer activities of some pyrrolopyrimidine derivatives were evaluated. Compound 3 is the most cytotoxic compound on MCF-7 cancer cells with an IC50 value of 23.42 mu M. Also, compound 3 induced apoptosis and the ROS(+) cell population in MCF-7 cells. Moreover, it significantly reduced MMP-9 activity, having 42.16 +/- 5.10% and 58.28 +/- 1.96% inhibitory activities at 10 mu M and 50 mu M concentrations, respectively. Molecular docking results supported the activity, showing key hydrogen bonds with the binding site of MMP-9. Therefore, compound 3 might be a lead compound for the development of potent MMP-9 inhibitors.
引用
收藏
页码：3169 / 3177
页数：9
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