Long-Term Efficacy of Mepolizumab at 3 Years in Patients with Severe Asthma: Comparison with Clinical Trials and Super Responders

被引：12

作者：

Bagnasco, Diego ^{[1
,2
]}

Nicola, Stefania ^{[3
]}

Testino, Elisa ^{[1
,2
]}

Brussino, Luisa ^{[3
]}

Pini, Laura ^{[4
]}

Caminati, Marco ^{[5
]}

Piccardo, Federica ^{[2
]}

Canevari, Rikki Frank ^{[6
]}

Melissari, Laura ^{[1
,2
]}

Ioppi, Alessandro ^{[6
]}

Guastini, Luca ^{[6
]}

Lombardi, Carlo ^{[7
]}

Milanese, Manlio ^{[8
]}

Losa, Francesca ^{[9
]}

Robbiano, Michela ^{[1
,2
]}

De Ferrari, Laura ^{[1
,2
]}

Riccio, Anna Maria ^{[1
,2
]}

Guida, Giuseppe ^{[10
]}

Bonavia, Marco ^{[11
]}

Fini, Donatella ^{[12
]}

Balbi, Francesco ^{[13
]}

Caruso, Cristiano ^{[14
]}

Paggiaro, Pierluigi ^{[15
]}

Blasi, Francesco ^{[16
,17
,18
]}

Heffler, Enrico ^{[19
,20
]}

Paoletti, Giovanni ^{[19
,20
]}

Canonica, Giorgio Walter ^{[19
,20
]}

Senna, Gianenrico ^{[5
]}

Passalacqua, Giovanni ^{[1
,2
]}

机构：

[1] Univ Genoa, IRCCS Policlin San Martino, Allergy & Resp Dis, I-16132 Genoa, Italy

[2] Univ Genoa, Dept Internal Med DIMI, I-16132 Genoa, Italy

[3] AO Ordine Mauriziano Torino, SCDU Immunol & Allergol, Cso Re Umberto 109, I-10128 Turin, Italy

[4] Spedali Civili Brescia, Resp Med Unit, Piazzale Spedali Civili 1, I-25123 Brescia, Italy

[5] Univ Verona, Dept Med, I-37134 Verona, Italy

[6] Univ Genoa, ENT Dept, IRCCS Policlin San Martino, I-16132 Genoa, Italy

[7] Fdn Poliambulanza, Dept Unit Allergol Immunol & Pulm Dis, I-25124 Brescia, Italy

[8] ASL2, S Corona Hosp, Dept Resp Dis, I-17027 Pietra Ligure, Italy

[9] ASST Mantova, UO Allergol & Clin Immunol, I-46100 Mantua, Italy

[10] Univ Torino, Dept Clin & Biol Sci, Orbassano 10043, Italy

[11] ASL3, Hosp Ge Arenzano, Dept Rehabil Pulmonol, I-16149 Genoa, Italy

[12] Hosp Sarzana SP, Dept Pneumol, I-19125 La Spezia, Italy

[13] Hosp Imperia, Dept Pneumol, I-18100 Imperia, Italy

[14] Univ Cattolica Sacro Cuore, Dept Med & Surg Sci, Fdn Universitary Policlin A Gemelli IRCCS, I-20123 Rome, Italy

[15] Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care, I-56126 Pisa, Italy

[16] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy

[17] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Resp Unit, I-20122 Milan, Italy

[18] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Adult Cyst Fibrosis Ctr, Internal Med Dept, I-20122 Milan, Italy

[19] IRCCS Human Clin & Res Hosp, Unit Personalized Med Asthma & Allergy, I-20089 Rozzano, Italy

[20] Humanitas Univ, Dept Biomed Sci, I-20072 Pieve Emanuele, Italy

来源：

BIOMEDICINES | 2023年 / 11卷 / 09期

关键词：

severe asthma; eosinophils; mepolizumab; CRSwNP; IL-5; real life; registry; SEVERE EOSINOPHILIC ASTHMA; MULTICENTER;

D O I：

10.3390/biomedicines11092424

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The efficacy mepolizumab in severe asthmatic patients is proven in the literature. Primarily to study the effect of mepolizumab on exacerbations, steroid dependence, and the continuation of efficacy in the long term. Secondarily to evaluate the effect of the drug on nasal polyps. Analyzing data from SANI (Severe Asthma Network Italy) clinics, we observed severe asthmatic patients treated with mepolizumab 100 mg/4 weeks, for a period of 3 years. 157 patients were observed. Exacerbations were reduced from the first year (-84.6%) and progressively to 90 and 95% in the second and third ones. Steroid-dependent patients decreased from 54% to 21% and subsequently to 11% in the second year and 6% in the third year. Patients with concomitant nasal polyps, assessed by SNOT-22, showed a 49% reduction in value from baseline to the third year. The study demonstrated the long-term efficacy of mepolizumab in a real-life setting.

引用

页数：10

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