Iron status and cardiometabolic risk in children

被引:1
作者
Suarez-Ortegon, Milton Fabian [1 ,2 ]
Prats-Puig, Anna [3 ,4 ]
Bassols, Judit [3 ,5 ]
Carreras-Badosa, Gemma [3 ,5 ]
Mclachlan, Stela [6 ]
Wild, Sarah H. [6 ]
Lopez-Bermejo, Abel [3 ,5 ,7 ,10 ,11 ]
Fernandez-Real, Jose Manuel [8 ,9 ,10 ,11 ]
机构
[1] Pontificia Univ Javeriana Secc Cali, Dept Alimentac & Nutr, Cali, Colombia
[2] Pontificia Univ Javeriana Secc Cali, Dept Comun Lenguaje, Cali, Colombia
[3] Girona Inst Biomed Res, Pediat Res Grp, Girona, Spain
[4] Univ Girona, Sch Med, Girona 17004, Spain
[5] Dr Josep Trueta Hosp, Dept Pediat, ES-17007 Girona, Spain
[6] Univ Edinburgh, Usher Inst, Edinburgh, Scotland
[7] Univ Girona, Dept Med Sci, Res Grp Clin Anat Embryol & Neurosci NEOMA, Girona 17004, Spain
[8] Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr, Girona 17007, Spain
[9] Inst Salud Carlos III ISCIII, Girona 17007, Spain
[10] Hosp Girona Dr JosepTrueta, Dept Pediat, Carretera Franca S-N, Girona 17007, Spain
[11] Hosp Girona Dr JosepTrueta, Dept Diabet Endocrinol & Nutr, Carretera Franca S-N, Girona 17007, Spain
关键词
Transferrin; Ferritin; Metabolic syndrome; Insulin resistance; Glycosylated haemoglobin; Children; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; INSULIN-RESISTANCE; PUBERTAL CHANGES; DEFICIENCY; ADOLESCENTS; TRANSFERRIN; PREVALENCE; FERRITIN; GLUCOSE;
D O I
10.1016/j.diabres.2023.110795
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: We aimed to evaluate associations between serum ferritin and transferrin and variables related to the metabolic syndrome (MetS) in children. Methods: Cross-sectional and longitudinal study in prepubertal children (n = 832) aged 3-14 years. A subset (n = 203) were re-examined after a mean follow-up of 3.7 +/- 0.8 years[range 2-6]. Outcomes were MetS and MetS components scores, glycosylated haemoglobin (HbA1c), and their follow-up change. Results: Children with low ferritin had increased HbA1c Z scores (ANCOVA, P = 0.003). Ferritin was inversely associated with glycaemia [fully adjusted beta (95% confidence interval): 2.35( 4.36 to 0.34)]. Transferrin was associated with diastolic blood pressure [beta: 0.02(0.01-0.04)] and log-HOMA-IR [beta:0.001(0.0005-0.002)]. MetS risk score worsened during follow-up in children with the lowest baseline ferritin levels. In contrast, at baseline ferritin was positively associated with all (except glycaemia) the MetS-related variables but adjustments for inflammatory, hepatic function, and body mass markers attenuated those associations (P > 0.05). Conclusions: Lower iron status was independently associated with glycaemic markers and MetS in children, whereas higher ferritin levels were related to other cardiometabolic risk markers under the influence of inflammation, hepatic injury and body mass. Research is required to study whether this mixed pattern is part of an early risk or would be explained by a normal transition during growth and development.
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页数:10
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