Comparative Analysis of the Effect of Native and Polymeric ß-Cyclodextrins on the Solubility and Membrane Permeability of Baricitinib

A study is performed of the effect native and polymeric beta-cyclodextrins have on the solubility and membrane permeability of baricitinib, a new generation immunomodulator. It is found that native and polymeric beta-cyclodextrins exhibit the same solubilizing effect in relation to baricitinib, while their effect on the membrane permeability of the drug differs. The increased solubility of baricitinib is due to the formation of inclusion complexes that have the same stability but are enthalpy-entropy stabilized in native beta-cyclodextrin and enthalpy stabilized in polymeric beta-cyclodextrin. The effect cyclodextrins on baricitinib's coefficients of permeability of through a model membrane is discussed in terms of complexation, changes in the viscosity of the medium, and the state of the water boundary layer near the membrane's surface.