Recent advances in the tumor-penetrating peptide internalizing RGD for cancer treatment and diagnosis

被引:13
作者
Qian, Jing [1 ,2 ,3 ]
Zhou, Sheng [4 ]
Lin, Peng [2 ,3 ]
Lei, Jin [3 ]
Zheng, Shiqi [3 ]
Xu, Wenmang [3 ]
Wang, Yuanyuan [3 ]
Gao, Ziran [3 ]
Yang, Julun [3 ,5 ]
机构
[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Peoples R China
[2] Kunming Univ Sci & Technol, Med Sch, Kunming, Peoples R China
[3] 920th Hosp Joint Logist Support Force PLA, Dept Pathol, Kunming, Peoples R China
[4] Third Peoples Hosp Yunnan Prov, Dept Med Adm, Kunming, Peoples R China
[5] 920th Hosp Joint Logist Support Force PLA, Dept Pathol, 212 Daguan Rd, Kunming 650032, Peoples R China
关键词
drug delivery; iRGD; tumor penetrating and targeting; tumor treatment; 3D MULTICELLULAR SPHEROIDS; MODIFIED THYMOSIN ALPHA-1; DRUG-DELIVERY SYSTEM; TARGETED CO-DELIVERY; BREAST-CANCER; IRGD PEPTIDE; IN-VITRO; ANTITUMOR-ACTIVITY; ANTI-ANGIOGENESIS; LUNG-CANCER;
D O I
10.1002/ddr.22056
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Cancer has become a prominent disease that seriously endangers human health. The complexity of the biological characteristics of the tumor makes it challenging for traditional therapeutic drugs to penetrate tumor tissues and exert their antitumor effects. Internalizing RGD peptide (iRGD) is a novel tumor-homing peptide that binds to alpha v beta 3 and alpha v beta 5 integrins on the surface of tumor vessels through the C-end rule (CendR) motif. The CendR motif binds to the neuropilin-1 (NRP-1) receptor on tumor cells, initiating NRP-1-mediated transcytosis to facilitate drug entry into the tumor tissue. Multiple studies demonstrated that iRGD improved the penetration and targeting of antitumor drugs, thereby enhancing their antitumor efficacy. In this review, we initially described the origins of iRGD and its penetration mechanism. Furthermore, we presented updates on the application of iRGD in cancer chemotherapy, photodynamic therapy, gene therapy, immunotherapy, treatment with antibodies or protein-based biologics, and tumor imaging.
引用
收藏
页码:654 / 670
页数:17
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