An entropy-driven DNA nanomachine for microRNA detection using a personal glucose meter

被引：17
|
作者：
Wang, Qing [1 ]
He, Yuqiu [1 ]
He, Shizhen [1 ]
Yu, Shanshan [1 ]
Jiang, Yuqian [1 ]
Wang, Fuan [1 ,2 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
[2] Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan, Hubei, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 10期
基金：
中国国家自然科学基金;
关键词：
OF-CARE DIAGNOSTICS; LUNG-CANCER; SYSTEM;
D O I：
10.1039/d2cc06479k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we developed a reliable and portable biosensor (TDR-PGM nanomachine) for the sensitive detection of microRNA by integrating an efficient toehold-mediated strand displacement reaction module (TDR) and a personal glucose meter (PGM). The system provides a versatile methodology for microRNA detection in real samples and holds broad prospects in point-of-care diagnosis.
引用
收藏
页码：1345 / 1348
页数：4
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