Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review

被引:5
作者
Li, Jun [1 ,2 ]
Yu, Ya-Fen [1 ]
Qi, Xiao-Wei [3 ]
Du, Yuan [1 ]
Li, Chun-Qing [1 ]
机构
[1] Jiangnan Univ, Dept Nephrol, Affiliated Hosp, Wuxi, Jiangsu, Peoples R China
[2] Jiangnan Univ, Wuxi Sch Med, Wuxi, Jiangsu, Peoples R China
[3] Jiangnan Univ, Dept Pathol, Affiliated Hosp, Wuxi, Jiangsu, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 13卷
关键词
immune checkpoint inhibitors; immune-related adverse; glucocorticiods; case report; literature review; NIVOLUMAB;
D O I
10.3389/fimmu.2022.1051577
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immune checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA4) and anti-programmed death cell protein 1 (anti-PD-1), are increasingly prescribed in metastatic carcinoma therapy. ICI-related kidney injury is gradually recognized by clinicians. However, immune-related ureteritis and cystitis easily go undiagnosed. We report three cases of PD-1 monoclonal antibody (mAb)-related ureteritis and cystitis. We further carried out a review of the literature about ICI-related ureteritis and cystitis. The cases in our reports manifest urinary irritation, sterile pyuria, gross hematuria, hydronephrosis, dilation of the ureters, and acute kidney injury. Urinary irritation improved effectively; urinalysis and renal function returned to normal after glucocorticoid therapy. During ICI therapy, urinalysis and renal function and urinary imaging examination are recommended to be monitored regularly. It contributes to identify immune-related ureteritis/cystitis earlier to efficiently alleviate urinary symptoms and immunologic urinary tract injury through glucocorticoid therapy while avoiding the abuse of antibiotics.
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页数:9
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