Application of Extracellular Vesicles in Allergic Rhinitis: A Systematic Review

被引:6
作者
Czerwaty, Katarzyna [1 ]
Dzaman, Karolina [1 ]
Miechowski, Wiktor [1 ]
机构
[1] Ctr Postgrad Med Educ, Dept Otolaryngol, Marymoncka 99-103, PL-01813 Warsaw, Poland
关键词
allergic rhinitis; extracellular vesicles; exosomes; miRNA; LncRNA; liquid biopsy; MESENCHYMAL STEM-CELLS; NASAL-MUCOSA; AIRWAY INFLAMMATION; NONCODING RNAS; T-CELLS; IMMUNOTHERAPY; MICROBIOTA; MATURATION; ASTHMA; TH1;
D O I
10.3390/ijms24010367
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The pathophysiology of allergic rhinitis (AR), one of the most common diseases in the world, is still not sufficiently understood. Extracellular vesicles (EVs), which are secreted by host and bacteria cells and take part in near and distant intracellular communication, can provide information about AR. Recently, attention has been drawn to the potential use of EVs as biomarkers, vaccines, or transporters for drug delivery. In this review, we present an up-to-date literature overview on EVs in AR to reveal their potential clinical significance in this condition. A comprehensive and systematic literature search was conducted following PRISMA statement guidelines for original, completed articles, available in English concerning EVs and AR. For this purpose, PubMed/MEDLINE, Scopus, Web of Science, and Cochrane, were searched up until 10 Novenmber 2022. From 275 records, 18 articles were included for analysis. The risk of bias was assessed for all studies as low or moderate risk of overall bias using the Office and Health Assessment and Translation Risk of Bias Rating Tool for Human and Animal Studies. We presented the role of exosomes in the pathophysiology of AR and highlighted the possibility of using exosomes as biomarkers and treatment in this disease.
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页数:17
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