Omics-based molecular classifications empowering in precision oncology

被引：10

作者：

Zhou, Zhaokai ^{[1
,2
]}

Lin, Ting ^{[1
]}

Chen, Shuang ^{[3
]}

Zhang, Ge ^{[4
]}

Xu, Yudi ^{[5
]}

Zou, Haijiao ^{[3
]}

Zhou, Aoyang ^{[1
]}

Zhang, Yuyuan ^{[1
]}

Weng, Siyuan ^{[1
]}

Han, Xinwei ^{[1
,6
,7
]}

Liu, Zaoqu ^{[1
,6
,7
,8
]}

机构：

[1] Zhengzhou Univ, Dept Intervent Radiol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Dept Urol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[3] Zhengzhou Univ, Ctr Reprod Med, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[4] Zhengzhou Univ, Dept Cardiol, Affiliated Hosp 1, Zhengzhou, Peoples R China

[5] Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[6] Zhengzhou Univ, Intervent Inst, Zhengzhou 450052, Henan, Peoples R China

[7] Intervent Treatment & Clin Res Ctr Henan Prov, Zhengzhou 450052, Henan, Peoples R China

[8] Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Beijing 100730, Peoples R China

来源：

CELLULAR ONCOLOGY | 2024年 / 47卷 / 03期

关键词：

Omics biomarkers; Molecular classification; Precision oncology; Clinical translation; SOCS3;

D O I：

10.1007/s13402-023-00912-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundIn the past decades, cancer enigmatical heterogeneity at distinct expression levels could interpret disparities in therapeutic response and prognosis. It built hindrances to precision medicine, a tactic to tailor customized treatment informed by the tumors' molecular profile. Single-omics analysis dissected the biological features associated with carcinogenesis to some extent but still failed to revolutionize cancer treatment as expected. Integrated omics analysis incorporated tumor biological networks from diverse layers and deciphered a holistic overview of cancer behaviors, yielding precise molecular classification to facilitate the evolution and refinement of precision medicine.ConclusionThis review outlined the biomarkers at multiple expression layers to tutor molecular classification and pinpoint tumor diagnosis, and explored the paradigm shift in precision therapy: from single- to multi-omics-based subtyping to optimize therapeutic regimens. Ultimately, we firmly believe that by parsing molecular characteristics, omics-based typing will be a powerful assistant for precision oncology.

引用

页码：759 / 777

页数：19

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