Pd(II)-Catalyzed C-H Silylation of o-Alkynylanilines Initiated by an Aminopalladation To Access Disilylated 2-Phenyl-1H-indoles

被引：3

作者：

Chen, Yan ^{[1
,2
]}

Zhu, Ling ^{[1
,2
]}

Tan, Xuliang ^{[1
,2
]}

Chen, Xiahong ^{[1
,2
]}

Deng, Guobo ^{[1
,2
]}

Liang, Yun ^{[1
,2
]}

Yang, Yuan ^{[1
,2
]}

机构：

[1] Hunan Normal Univ, Natl & Local Joint Engn Lab New Petro Chem Mat & F, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ,Coll Chem & Chem Engn, Changsha 410081, Peoples R China

[2] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Changsha 410081, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 02期

基金：

中国国家自然科学基金;

关键词：

C; C-palladacycles; C-H silylation; o-alkynylanilines; aminopalladation; disilylated; 2-phenyl-1H-indoles; DIRECT INTERMOLECULAR SILYLATION; STEREOSELECTIVE-SYNTHESIS; ACTIVATION; GERMANYLATION; DIVERGENT; FUNCTIONALIZATION; PALLADACYCLES; VINYLSILANES; ALKENES; ALKYNES;

D O I：

10.1002/adsc.202301119

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein a Pd(II)-catalyzed C-H silylation of o-alkynylanilines with hexamethyldisilane for the synthesis of disilylated 2-phenyl-1H-indoles is reported. In this reaction, o-alkynylanilines undergo an aminopalladation, C-H activation, and dealkylation sequence to form five-membered C,C-palladacycles, which then couple with hexamethyldisilane to construct one C-N bond and two C-Si bonds. This method provides an alternative strategy for C-H silylation.

引用

页码：183 / 187

页数：5

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